慢性糜烂性胃炎与胃癌的免疫组织化学比较研究——P^(21ras)、 P^(53)、PCNA和CEA表达的观察  

Comparative Immunohistochemical Study Between Chronic Erosivc Gastritisand Gastric Carcinoma——Observation of Expression of P^(21), P^(53), PCNA andCEA

作　　者：柯昌庶[1] 王伟[1] 王一鸣[2] 李道芬[2] 

机构地区：[1]广州军区武汉总医院病理科,武汉430070 [2]广州军区武汉总医院消化科,武汉430070

出　　处：《临床消化病杂志》1997年第1期7-10,共4页Chinese Journal of Clinical Gastroenterology

摘　　要：本研究对31例慢性糜烂性胃炎粘膜活检组织及14例手术切除的胃癌组织的P21ras、P53蛋白、细胞核增殖抗原（PCNA）、癌胚抗原（CEA）的表达采用LSAB免疫组织化学标记。结果发现P21ras在慢性糜烂性胃炎粘膜上皮和胃癌肿瘤细胞中表达阳性率分别为67.7％和65.0％（P>0.05）;P53表达阳性率分别为0和21.4％（0.01<P<0.05）;PCNA表达阳性率分别为67.7％和93.0％（P>0.05）;CEA表达阳性率分别为29.0％和78.6％（P<0.01）。慢性糜烂性胃炎较高的P21ras表达和较高的细胞增生活性（PCNA表达）,提示其有一定的转化趋势。慢性糜烂性胃炎粘膜上皮的CEA表达可能提示其为今后发展成肠型胃癌的前驱病变。Comparative study on expression of P21, P53, PCNA and CEA between 31 mucosal biopsy specimen and 14 resected gastric carcinomas were performed. Labelled-streptavidin biotin immunohistochemical method was used. Results showed that, in the chronic erosive gastritis and gastric carcinoma group, the positive rates of P21 were 67. 7% and 65.0%, respectively (P > 0. 05); one of P53 were 0% and 21.4% (0.01<P<0. 05); ones of PCNA were 67.7 % and 93.0 % (P > 0.05); onus of CEA were 29.0 % and 78.6% (P<0.05) with the same membrane type positive pattern in above two groups. Therefore, similar expression of P21 and higher cellular proliferating activity (PCNA expression) like gastric carcinoma indicate that there are certain transforming potentials in the lesions of chronic erosive gastritis. The expression of CEA in mucosal epithelia of chronic erosive gastriti suggest that the positive epithelia may be precursor of gastric carcinoma of intestinal type.

关 键 词：胃炎 胃癌 免疫组织化学 

分 类 号：R735.203[医药卫生—肿瘤]