转化生长因子-β3对肝脏和胰腺纤维化的影响  

Effect of transforming growth factor-β3 on hepatic and pancreatic fibrosis

作　　者：周霞[1] 徐可树[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院消化内科,湖北省武汉市430022

出　　处：《世界华人消化杂志》2007年第28期3011-3014,共4页World Chinese Journal of Digestology

摘　　要：组织纤维化的基本特征是细胞外基质降解减少、过度沉积,导致组织结构的改建.TGF-β3通过抑制胶原的沉积,促进其降解而具有抗纤维化作用,并被证实在创伤愈合过程中可减轻伤后疤痕的形成.本文着重介绍了TGF-β3在肝脏及胰腺纤维化中的表达及其作用,以进一步了解其对纤维化疾病的影响.Excessive deposition of extracellular matrix leading to tissue reconstruction is the basic characteristic of tissue fibrosis. Transforming growth factor （TGF）-β3 has an anti-fibrotic effect through inhibiting the deposition of collagen and promoting its decomposition. Furthermore, it has been shown that TGF-β3 can decrease scar formation during wound healing. We focused on the expression and effect of TGF-β3 in the course of hepatic and pancreatic fibrosis, then investigated the effect of TGF-β3 on fibrosis.

关 键 词：转化生长因子-Β3 肝纤维化 胰腺纤维化 

分 类 号：R575.2[医药卫生—消化系统] R576[医药卫生—内科学]