调强放疗治疗复发性子宫颈癌的初步报告  

Preliminary study of intensity-modulated radiation therapy for recurrent cervical cancer

作　　者：周琦[1] 唐郢[1] 舒小蕾[1] 刘俐[1] 

机构地区：[1]重庆市肿瘤研究所妇瘤科,400030

出　　处：《中华妇产科杂志》2007年第11期730-732,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的初步探讨调强放疗(IMRT)治疗复发性宫颈癌的近期疗效及并发症的发生情况。方法收集重庆市肿瘤研究所2004年4月至2007年1月间实施 IMRT 治疗复发性宫颈癌患者21例(观察组)的临床资料,并以同期采用盆腔前后野照射治疗的复发性宫颈癌患者18例作为对照组。比较两组患者的近期疗效和并发症的发生情况。结果观察组完成外照射肿瘤剂量为(50±11)Gy,对照组完成外照射肿瘤剂量(39±5)Gy,两组比较,差异无统计学意义(P>0.05);观察组的有效率为71%(15/21),对照组为39%(7/18),两组比较,差异有统计学意义(P<0.05);观察组平均生存时间为(25±6)个月,对照组为(12±5)个月,两组比较,差异有统计学意义(P<0.05)。观察组无Ⅲ级以上的急性放射性胃肠道、泌尿生殖道反应发生,2例出现Ⅲ度骨髓抑制;对照组无Ⅲ级以上的急性放射性胃肠道、泌尿生殖道反应及Ⅲ度以上骨髓抑制发生。结论 IMRT 治疗复发性宫颈癌的近期疗效优于盆腔前后野照射,且其近期并发症的发生率并不增加。Objective To assess feasibility of intensity-modulated radiation therapy for recurrent cervical cancer. Methods Totally 21 patients with recurrent cervical cancer between April 2004 and January 2007 treated with intensity-modulated radiation therapy （IMRT）and conventional external radiation therapy were evaluated. Twenty-one patients treated with IMRT was group A, and the other 18 patients with anterior posterior field radiotherapy was group B. Preliminary outcome and toxicity were evaluated between two groups. Results All patients completed the prescribed dose. Group A was （ 50 ± 11 ） Gy and group B was （ 39 ± 5 ） Gy. There were no significant differences in the two groups （ P 〉 0. 05 ）. The effective rate of group A was 71% （15/21） and of group B 39% （7/18）, with a significant difference in the two groups （P 〈0. 05 ）. The average survival time of group A was （25 ± 6） months, and of group B （12 ± 5 ） months, with a significant difference in the two groups （ P 〈 0. 05）. In group A, acute grade ≥3 gastrointestinal, genitourinary, and myelotoxicity were seen in 0, 0, and 2 patients, respectively. While in group B, these were seen in none. Conclusions The curative effect of IMRT is better than anterior posterior field radiotherapy. The acute toxicity of IMRT is acceptable.

关 键 词：宫颈肿瘤 肿瘤复发 局部 放射疗法 

分 类 号：R737.33[医药卫生—肿瘤]