双氯酚酸和罗非考昔抑制鼠牙移动的效果比较  

Inhabition to orthodontic tooth movement in rats between diclofenac and rofecoxib.

作　　者：刘长庚 王月辉 刘友良 张清 

机构地区：[1]益阳高等医学专科学校口腔中心,湖南益阳413000

出　　处：《临床口腔医学杂志》2007年第11期670-672,共3页Journal of Clinical Stomatology

摘　　要：目的:比较罗非考昔和双氯酚酸对大鼠正畸牙移动的影响。方法:42只雄性Wistar大鼠分成6个实验组:1、2、3组均给予50g正畸力,分别注射罗非考昔、双氯酚酸或生理盐水;4、5、6组均给予100g正畸力,亦分别注射上述三种药物。结果:用药7d后测量鼠牙移动情况:罗非考昔和双氯酚酸均能抑制牙移动,但二者差异无统计学意义。结论:罗非考昔和双氯酚酸在缓解正畸治疗炎性疼痛的同时,均有减慢牙移动的副作用,且二者副作用对正畸牙矫治效果无实质性差异。Objective：The purpose of this study was to compare the effects of the inhabition to orthodontic tooth movement in rats between diclofenac [a nonspecific cyclooxygenase （COX） inhibitor, or a conventional nonsteroidal antiinflammatory drug ] . Method：42 male wistar rats in 6 experimental groups： （1） （2） （3）50 g coil spring and injections of rofecoxib, diclofenac or saline-solution, respectively, and （4） （5） （6）100 g coil spring and the same pharmacological treat- ment as （1） （2） （3）, respectively. Result： After 7 days, both rofecoxib and diclofenac significantly inhibited tooth movement, but not reached statistically significant differences. Conclusion： Both rofecoxib and diclofenac have side effect to inhibit tooth movement. When they are used for treating inflammation and pain, there are no substantial differences.

关 键 词：双氯酚酸 罗非考昔 COX 口腔正畸 牙移动 

分 类 号：R783.5[医药卫生—口腔医学]