磷酸化STAT3和磷酸化Akt在黑素瘤中的过度表达与肿瘤浸润及转移相关性研究  

Overexpression of phosphorylated-STAT3 and phosphorylated-Akt correlated with the invasion and metastasis of malignant melanoma

作　　者：林能兴[1] 黄长征[1] 刘厚君[1] 刘志香[1] 占部和敬 古江增隆[2] 涂亚庭[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,湖北武汉430030 [2]日本九州大学附属医院皮肤科,福冈800812

出　　处：《临床皮肤科杂志》2007年第11期679-681,共3页Journal of Clinical Dermatology

基　　金：国家自然科学基金资助项目(30671891)

摘　　要：目的:了解磷酸化细胞信号传导与转录活化因子3(phosphorylated signal tranducers and activators of transcription,p-STAT3)和磷酸化Akt(p-Akt)在黑素瘤中的表达及与肿瘤浸润、转移的关系;方法:采用免疫组化法检测41例黑素瘤和23例色素痣中的p-STAT3和p-Akt,评估它们与肿瘤浸润、转移的关系。结果:p-STAT3在23例色素痣中有2例表达阳性,在41例黑素瘤中有29例表达阳性;p-Akt在23例色素痣中有3例表达阳性,41例黑素瘤中有26例表达阳性,经卡方检验,P<0.05,差异有统计学意义。在黑素瘤中,p-STAT3与p-Akt的阳性表达之间呈正相关,并且p-STAT3和p-Akt的表达阳性率在有浸润或转移的黑素瘤中远高于无浸润或转移的黑素瘤,差异有统计学意义。结论:p-STAT3和p-Akt在黑素瘤的发病、浸润及转移机制中具有重要作用。Objective： To evaluate expression of p-STAT3 and p-Akt in malignant melanoma and their relationship with invasion and metastasis of the tumor. Methods： The expression of p-STAT3 and p-Akt in 23 cases of melanocytic nevi and 41 cases of malignant melanoma using immunohistochemistry was examined, and the relationship between the expression of p- STAT3 and p-Akt in malignant melanomas and invasion and metastasis of the tumors was evaluated. Results： The expression of p-STAT3 was seen in two of 23 cases of melanocytic nevi and in 29 of 41 cases of malignant melanoma, while p-Akt was expressed in 3 of 23 cases of melanocytic nevi and 26 of 41 cases of malignant melanoma, indicating that the expression of p-STAT3 and p-Akt in melanoma was significantly higher than that in benign nevi. There was significant correlation between the expression of p-STAT3 and p-Akt in melanoma. Furthermore, the expression rates of p-STAT3 and p-Akt were significantly higher in invasive or metastatic melanomas than those in non-invasive or non-metastatic melanomas. Conclusion： p- STAT3 and p-Akt may play important roles in the pathogenesis of malignant melanoma, and their expression may correlate with the invasion and metastasis of tumors.

关 键 词：磷酸化细胞信号传导与转录活化因子3 磷酸化AKT 黑素瘤 色素痣 

分 类 号：R739.5[医药卫生—肿瘤]