CerbB-2和PCNA在乳腺癌中的表达与淋巴结转移的相关性分析  

Relationship between the expression of CerbB-2 and PCNA in breast cancer and the lymphatic metastasis

作　　者：洪月琳[1] 杨培民[1] 耿海涛[1] 王秀玲[2] 

机构地区：[1]上海市第七人民医院普外科,上海200137 [2]上海市第七人民医院病理科,上海200137

出　　处：《中国肿瘤临床与康复》2007年第5期406-408,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的分析乳腺癌CerbB-2、PCNA的表达与腋窝淋巴结、肿瘤大小、年龄、病理类型的相关性。方法应用免疫组化Envison二步法对180例原发性乳腺癌行根治及改良根治术的标本进行了CerbB-2、PCNA的检测,并进行统计学分析。结果CerbB-2、PCNA的阳性表达率分别为35.6%(64/180)和41.7%(75/180);CerbB-2、PCNA的阳性表达率与淋巴结转移有关(P<0.01),而与患者年龄、肿瘤大小及乳腺癌组织学类型无关(P>0.05)。结论CerbB-2、PCNA的阳性表达与淋巴结转移程度呈正相关,与肿瘤大小、年龄、病理类型不相关。CerbB-2、PCNA可作为判断乳腺癌预后的指标。Objective To investigate the relationship between the expression of CerbB-2 and PCNA in breast cancer and the auxiliary lymph nodes, tumor size, age, pathological type of cancer in breast cancer patients. Methods Immunohistochemical two-step Envison method was used for the detection of CerbB-2 and PCNA in specimens taken from 180 breast cancer patients undergoing radical treatment or modified radical treatment, x^2 Statistical analysis was used. Results The positive expression rates of CerbB-2 and PCNA were 35.6% （64/180）and 41.7% （75/180）respectively,and the positive expression rates of them were associated with lymph node metastasis （P 〈 0.01 ）, but not related to patient＇ s age, tumor size, and histological type （P 〉 0.05）. Condusion The positive expression rates of CerbB-2 and PCNA were related to lymph node metastasis, but not related to patient＇ s age, tumor size and histological type. They can be used to predict the prognosis of breast cancer patients.

关 键 词：乳腺肿瘤 CERBB-2 PCNA 

分 类 号：R737.9[医药卫生—肿瘤] R730.43[医药卫生—临床医学]