膀胱癌手术时黏膜下注射羟基喜树碱及术后膀胱灌注的疗效观察  

Observation on efficacy of intraoperative submucosal injection of HCPT and postoperative bladder irrigation in treatment of bladder cancer

作　　者：项文英[1] 付成[1] 

机构地区：[1]辽宁省肿瘤医院泌尿外科,沈阳110042

出　　处：《中国肿瘤临床与康复》2007年第5期433-434,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨膀胱癌切除术后预防肿瘤复发的治疗方案。方法切除肿瘤缝合后,将羟基喜树碱20 mg稀释后进行膀胱黏膜下局部浸润注射,术后用羟基喜树碱20 mg定期膀胱内灌注。结果213例中185例获5年内随访,其中3年以上者121例,占65.4%;2年以上者39例,占21.1%;1年以上者25例,占13.5%;总有效率87.6%。仅有23例术后复发,复发率为12.4%。结论膀胱肿瘤切除缝合后,应用羟基喜树碱20 mg稀释后行黏膜下注射和术后定期行膀胱内灌注,方法简便,费用低,疗效可靠,可防止膀胱癌复发。Objective To explore the treatment scheme of preventing the relapse of tumor after the operation of the bladder cancer. Methods The diluted HCPT 20 mg was injected into the submucosa of bladder after tumor resection and irrigated the bladder regularly after operation. Results 185 of the total 213 patients were followed up after operation. Of them, 121 were followed up for more than 3 years ,39 for more than 2 years and 25 for more than 1 year. The overall effective rate was 87.6%. Only 23 cases relapsed after operation, with relapse rate of 12.4%. The rest of the cases did not relapse. Conclusion Injection of diluted HCPT into submucosa of bladder after tumor resection and regular irrigation of the bladder after operation were simple, low expense, reliable in therapeutic efficacy and can prevent the relapse of bladder cancer.

关 键 词：膀胱肿瘤 羟基喜树碱 黏膜注射 膀胱灌注 

分 类 号：R737.14[医药卫生—肿瘤] R730.53[医药卫生—临床医学]