维甲酸硅油的视网膜毒性实验研究  

THE EVALUATION OF TOXICITY OF RETINOIC ACID IN SILICONE OIL TO RETINAL TISSUE

作　　者：栾洁[1,2] 王文吉[1,2] 陈钦元[1,2] 赵培泉 

机构地区：[1]上海医科大学眼耳鼻喉科医院眼科 [2]南京铁道医学院附属医院

出　　处：《中华眼底病杂志》1997年第2期81-82,共2页Chinese Journal of Ocular Fundus Diseases

基　　金：1994年高校博士点基金

摘　　要：目的：了解维甲酸硅油对视网膜是否产生毒性。方法：１２只新西兰白兔的２４只眼，随机分为３组，行气体压迫玻璃体手术３天后，分别向玻璃体腔内注入硅油（４只眼）、５μｇ／ｍｌ维甲酸硅油（１０只眼）、１０μｇ／ｍｌ维甲酸硅油（１０只眼）各０．５ｍｌ，用检眼镜、光镜和电镜检查来观察视网膜变化情况。结果：注入硅油２８天后，未发现各浓度的维甲酸硅油对视网膜产生毒性作用。结论：浓度为５、１０μｇ／ｍｌ的维甲酸硅油注入玻璃体腔４周，对视网膜不产生毒性作用。OBJECTIVE:To evaluate the toxicity of retinoic acid in silicone oil to the retinal tissue.METHOD:Twelve New Zealand white rabbits(24 eyes)were divided into three grorps at random.Three days after gas compression vitrectomy,24 eyes were unedrgone gas/silicone oil exchange.The silicone oil 0.5 ml was injected intravitreally in 4 eyes as controls,and 5μg/ml retinoic acid silicone oil 0.5 ml in 10 eyes and 10 μg/ml retinoic acid silicone oil 0.5 ml in 10 eyes respectively as 2 study groups.After intravitreal injections,all the eyes were examined by ophthalmoscopy on the lst,3rd,7th,14th,21st and 28th day.The retinas of the enucleated eyes on the 28th day were then examined by light microscopy and transmission electrone microscopy.RESULT:No evidence of toxicity was found in retinas after intravitreal injections of silicone oil with 5 μg/ml or 10 μg/ml retinoic acid.CONCLUSION:There was no toxic effect on the retinas by using 5 μg/ml or 10 μg/ml retinoic acid in intravitreal silicone oil tamponade operation.

关 键 词：维甲酸硅油 眼科手术 视网膜脱落 视网膜病变 

分 类 号：R779.6[医药卫生—眼科] R774.12[医药卫生—临床医学]