集落刺激因子1及其受体的单抗对人肝癌细胞在裸鼠体内生长的抑制作用  

BIOLOGICAL EFFECT OF MONOCLONAL ANTIBODIES AGAINST CSF1 & CSF 1R ON HUMAN HEPATIC CANCER CELLS TRANSPLANTED IN NUDE MICE

作　　者：钱连芳[1,2] 吴克复 耿以琪[1,2] 姚明 田培坤[1,2] 万大方[1,2] 顾健人[1,2] 

机构地区：[1]上海市肿瘤研究所癌基因与相关基因国家重点实验室 [2]中国医学科学院.中国协和医科大学血液病研究所

出　　处：《肿瘤》1997年第4期307-308,共2页Tumor

摘　　要：探讨集落刺激因子┐１及其受体在人原发性肝癌中的过量表达及其意义。方法抗ＣＳＦ１Ｒ和抗ＣＳＦ１单克隆抗体对裸鼠移植性人肝癌７７２１细胞的生物学作用。结果两个单抗分别以７４．８８％和７７．９３％的体积抑瘤率在裸鼠体内抑制７７２１细胞的生长。结论ＣＳＦ１Ｒ和ＣＳＦ１可能是一新发现的肝癌自泌和旁泌系统。Objective:Over expression of colony stimulating factor 1 receptor (CSF 1R) in human primary hapatic cancer was studied Methods: Monoclonal antibodies (MAb) against CSF 1R and CSF1 were utilized to test there biological effect on human 7721 hepatic cancer cells transplanted in nude mice Results: MAb against CSF1 (B5) and MAb against CSF 1R (RE2) could inhibit the growth of 7721 cells in vivo by a rate of 74 88% and 77 93% respectively. Conclusions: CSF 1R and possibly CSF1 might be a new autocrine/paracrine system for human primary hepatic cancer.

关 键 词：集落刺激因子1 受体 肝癌细胞株 生长抑制 

分 类 号：R735.702[医药卫生—肿瘤]