Fascin在乳腺增生症和乳腺癌中的表达  

Expression of Fascin in Breast Hyperplasia and Breast Cancer

作　　者：崔迎彬[1] 孟庆敏[2] 陈虹[1] 黄秉仁[1] 

机构地区：[1]中国协和医科大学基础医学院/中国医学科学院基础医学研究所医学分子生物学国家重点实验室,北京100005 [2]首都医科大学附属北京同仁医院外科,100730

出　　处：《医学研究杂志》2007年第11期30-33,共4页Journal of Medical Research

基　　金：北京市自然科学基金资助项目(7042036)

摘　　要：目的探讨fascin在乳腺癌发病过程中的作用。方法用免疫组化方法检测20例乳腺导管上皮单纯性增生、9例乳腺导管上皮非典型性增生、25例乳腺浸润性导管癌患者中fascin的表达。结果Fascin在单纯性增生、非典型性增生、浸润性导管癌中的阳性率分别为95%、22.2%、8%。Fascin在导管上皮单纯性增生中的表达明显高于非典型性增生和浸润性导管癌(P<0.01)。结论Fascin在乳腺增生向乳腺癌的进展过程中可能起着某种作用,但目前尚难以作为乳腺癌诊断的分子标志。Objective To understand the roles of fascin in the stages of breast carcinogenesis. Methods Fascin expression was assessed via immunohistochemistry in 20 cases of breast ductal epithelial hyperplasia, 9 cases of breast atypical ductal hyperplasia and 25 cases of breast infiltrative ductal carcinoma. Results Fascin expression was found in 95 % of breast ductal epithelial hyperplasia, 22.2 % of breast atypical ductal hyperplasia and 8 % of breast infiltrative ductal carcinoma. Fascin expression in breast ductal epithelial hyperplasia was higher than that in breast atypical ductal hyperplasia and breast infiltrative ductal carcinoma （P 〈 0.01 ）. Conclusions Fascin may play an important biological role in the progression from breast ductal epithelial hyperplasia to breast infiltrative ductal carcinoma, but it is not a special molecular mark of breast cancer.

关 键 词：FASCIN 乳腺增生症 乳腺癌 免疫组织化学 

分 类 号：R655.8[医药卫生—外科学]