p21^(WAF1)基因遗传多态性与乳腺癌发病关系的风险  

Association of p21^(WAF1) gene polymorphism and susceptibities in breast carcinoma

作　　者：赵俊杰 朱岷[2] 黄铁生[2] 

机构地区：[1]河南省周口市中心血站,466000 [2]贵阳医学院附属医院

出　　处：《江苏医药》2007年第11期1110-1112,共3页Jiangsu Medical Journal

摘　　要：目的探讨p21WAF1基因多态性与乳腺癌遗传易感性之间的关系。方法应用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)方法检测117例乳腺癌患者和123例健康对照组外周血DNAp21WAF1基因第2外显子密码子31多态性的分布情况。结果乳腺癌与健康对照组间p21WAF1基因第2外显子密码子31的A(arginine)、C(serine)等位基因频率分别54.27%、45.73%及50.00%、50.00%(P>0.05)。携带Ser/Arg和Arg/Arg基因型的个体与携带Ser/Ser基因型的个体比较,乳腺癌患病风险无明显增加(OR,1.108;95%CI,0.579-2.122)。结论p21WAF1基因第2外显子密码子31多态性可能与贵州地区汉族妇女乳腺癌的发病风险无相关性。Objective To investigate the association of p21^WAF1 gene polymorphism with the susceptibility to breast cancer in Guizhou women. Methods The single nucleotide polymorphisms （SNPS） in codon 31 of p21^WAF1 gene were analyzed by polymorphism chain reaction-restriction fragment length polymorphism（PCR-RFLP） in 117 breast cancer patients and 123 healthy controls. Results The frequencies of A（arginine） and C（serine） allelotype in breast cancer patients and healthy controls were 54. 27 % vs. 45.73 % and 50. 00% vs. 50. 00%（P〉0. 05）. The patients with Ser/Arg and Arg/Arg genotypes were at a nonsignificant 1. 108-fold increased risk of breast cancer compared to the individuals with Ser/Ser genotype （95% CI, 0. 579- 2.12）. Conclusion In Guizhou women p21^WAF1 gene codon 31 polymorphism may not be associated with development of breast cancer.

关 键 词：乳腺肿瘤 P21^WAF1基因 多态现象(遗传学) 遗传易感性 

分 类 号：R737[医药卫生—肿瘤]