近红外光谱测定复方对乙酰氨基酚片的有效成分  

Determinations of the effective components in compound paracetamol based on near infrared spectroscopy

作　　者：蒋雪[1] 陈泽琴[2] 郭嘉伟[1] 谢洪平[1] 

机构地区：[1]苏州大学药学院,江苏苏州215123 [2]西华师范大学化学化工学院,四川南充637000

出　　处：《化学研究与应用》2007年第11期1255-1257,共3页Chemical Research and Application

基　　金：化学生物传感与计量学国家重点实验室开放基金(2003-16)资助项目;苏州大学优秀中青年学术带头人基金(R2317043)资助项目

摘　　要：Based on the near infrared diffuse reflectance spectroscopy,the analytical methods of the fast and simultaneous determinations for asipilin,paracetamol and caffeine contained in the compound paracetamol have been built by the partial least squares method.For the three drug components asipilin,paracetamol and caffeine,the correlation coefficients 0.9994,0.9903 and 0.9994 have been obtained,the root mean square errors(RMSE) of the calibration samples were 0.313,0.520 and 0.0301,and the RMSE-s of the prediction samples were 1.07,0.464 and 0.309,respectively.Based on the near infrared diffuse reflectance spectroscopy, the analytical methods of the fast and simultaneous determinations for asipilin, paracetamol and caffeine contained in the compound paracetamol have been built by the partial least squares method. For the three drug components asipilin, paracetamol and caffeine, the correlation coefficients 0. 9994, 0.9903 and 0. 9994 have been obtained, the root mean square errors （RMSE） of the calibration samples were 0. 313, 0. 520 and 0. 0301, and the RMSE - s of the prediction samples were 1.07, 0. 464 and 0. 309, respectively.

关 键 词：复方对乙酰氨基酚片 近红外光谱 偏最小二乘法 对乙酰氨基酚 阿司匹林 咖啡因 

分 类 号：O657.33[理学—分析化学]