MRI结合数字化钼靶诊断乳腺癌的临床研究  

Clinical Study of Digital Mammography,Contrast-enhanced MRI as Well as Their Combination in the Diagnosis of Breast Cancer

作　　者：叶芳[1] 曾蒙苏[1] 严福华[1] 凤伟[1] 周梅玲[1] 李轫晨[1] 陈文芳[1] 

机构地区：[1]复旦大学附属中山医院放射科,上海200032

出　　处：《放射学实践》2007年第11期1139-1143,共5页Radiologic Practice

摘　　要：目的:评价数字化钼靶与动态增强MRI检查及其联合应用对乳腺癌的诊断价值。方法:67例患者共78个经手术病理证实的乳腺病灶(恶性32个,良性46个),均经数字化钼靶及MRI检查(包括T1WI、T2WI、DWI和动态增强扫描)并进行BI-RADS分级,计算2种方法以及联合应用诊断乳腺病变的敏感度和特异度。结果:数字化钼靶和MRI对乳腺癌检出的敏感度分别为78.13%和93.75%,差异无统计学意义(P>0.05);两者对乳腺癌诊断的特异度分别为73.91%和89.13%,差异有统计学意义(P<0.05);两种方法联合运用检出病变的敏感度为98.63%,特异度为97.16%。结论:数字化钼靶摄片与MRI的联合应用有助于提高对乳腺癌的诊断准确性。Objective：To compare the effectiveness of digital mammography and MRI in the detection and diagnosis of breast cancer and to assess the value of these modalities as well as the combination of the two. Methods：Sixty-seven patients with surgery and pathology proved breast lesion （malignant, n=32; benign, n= 46） underwent digital mammography and MRI, the pulse sequences included Tt WI, T2 WI, diffuse weighted imaging （DWI）, and dynamic contrast-enhanced MRI before surgery. Of the results of these two modalities,all lesions were classified into 5 groups according to BI-RADS classification,and the imaging findings were correlated to histopathology. The sensitivity and specificity of each modality as well as the combination of the two were calculated. Results： Of these 78 breast lesions, the sensitivity was 78. 13% （25/32） for digital mammography and 93.75% （30/32） for MRI （P〉0. 05） ;the specificity was 73.91% （34/46） and 89.13% （41/46） accordingly （P（0.05）, both of them showed statistical difference. The sensitivity and specificity was 98.63 % and 97.16 % respectively as these two modalities were used in combination. Conclusion： Digital mammography in combination with MRI is helpful in the diagnosis of breast cancer,the sensitivity and soecificity was enhanced when comoared to that of single modalitv.

关 键 词：磁共振成像 乳腺肿瘤 乳房X线摄影术 

分 类 号：R737.9[医药卫生—肿瘤]