TNF相关的凋亡诱导配体与肿瘤  

TNF-related apoptosis-inducing ligand and tumor

作　　者：李红玲[1] 李景和[1] 

机构地区：[1]中南大学湘雅医学院病理学系,长沙410078

出　　处：《国际病理科学与临床杂志》2007年第5期406-410,共5页Journal of International Pathology and Clinical Medicine

摘　　要：TNF相关的凋亡诱导配体(TNF-related apoptosis-inducing ligand,TRAIL),属于TNF超家族成员,又称为Apo-2L,TRAIL能诱导多种肿瘤细胞的凋亡,而正常的细胞却对其不敏感,TRAIL主要通过与其受体结合激活caspase-8,启动非线粒体和线粒体依赖途径导致细胞凋亡。部分肿瘤细胞对TRAIL的敏感性较差,其原因与TRAIL的受体、信号转导途径激酶以及相关蛋白存在密切联系。TNF-related apoptosis-inducing ligand（TRAIL） is one of the members of TNF family,also known as Apo-2L.TRAIL can induce apoptosis of many kinds of cancer cells,whereas no-toxic to normal cells.TRAIL induces apoptosis through activation of its DRs,DR4 and DR5,then caspase-8 is activated,This leads to cleavage and activation of caspase-8 and the initiation of two different apoptotic pathways： mitochondrial-independent and mitochondrial dependent manner.However,many cancer cells in vitro are resistant to apoptosis-inducing effect of TRAIL,which are closely related to its receptors,protein kinases and some related proteins.

关 键 词：TNF相关的凋亡诱导配体 受体 信号途径 敏感性 肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]