腺苷受体在脑缺血中的研究进展  

Progression of adenosine receptor in cerebral ischemia

作　　者：柯荣湖[1] 刘颖[1] 

机构地区：[1]复旦大学上海医学院病理学系,上海200032

出　　处：《国际病理科学与临床杂志》2007年第5期443-447,共5页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金(30500189)~~

摘　　要：在脑缺血时,细胞外腺苷浓度急剧升高并激活各种腺苷受体。腺苷受体属于G蛋白偶联受体家族,目前已克隆出A1,A2a,A2b及A3四种腺苷受体亚型。它们广泛分布于中枢神经系统,并参与神经保护、反应性胶质化、炎症反应等病理过程。腺苷受体可能成为脑缺血时药物作用的新靶点。Concentration of adenosine is abruptly increasing when cerebral ischemia occurs,which can activate its receptors.Adenosine acts at four receptor subtypes,A1,A2a,A2b,and A3.All subtypes belong to the superfamily of G-protein coupled receptor.These receptors have a widely distribution in central nervous system and are involved in pathological processes including neuroprotection,reactive astrogliosis and inflammatory responses.Thus,adenosine receptors may become new pharmacological targets in cerebral ischemia.

关 键 词：腺苷受体 脑缺血 神经保护 

分 类 号：R743.3[医药卫生—神经病学与精神病学]