弓形虫感染对脑梗死患者血清MCP-1水平的影响  

The Influence of Toxoplasma Infection to the Serum Level of MCP-1 in Patients with Cerebral Infarction

作　　者：关国英[1] 韩辉[1] 代亚美[1] 路英[1] 靳轶敏[1] 王宇虹[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院干部一病房,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2007年第11期803-804,共2页Heilongjiang Medical Journal

基　　金：教育部及省留学回国基金(LC03C16)

摘　　要：目的探讨弓形虫感染对脑梗死患者血清单核细胞趋化蛋白-1(MCP-1)表达水平的影响。方法应用ELISA方法,对312例脑梗死患者和307例健康对照者进行弓形虫循环抗原CAg,弓形虫抗体IgM、IgG的定性检测及血清MCP-1表达水平测定。结果弓形虫感染的早期,脑梗死患者血清中MCP-1水平增高,经Mann-WhitneyU检验,P<0.05,统计学上有显著性意义。结论弓形虫感染的早期可致脑梗死患者血清MCP-1表达水平增高。Objective To investigate the relationship of toxoplasma infection and the serum level of MCP- 1 in patients with Cerebral Infarction （CT）. Methods The existence of the circulating antigen （CAg） and antibody IgM、IgG of toxoplasma and level of MCP-1 in serum was tested by ELISA in 312 patients with CI and 307 normal controls. Results There is a higher expression of MCP- 1 in patients with CI in the early stage of toxoplasma infection （ P 〈0.05）.Conclusion The early stage of toxoplasma infection may be able to cause a higher expression of MCP - 1 in patients with CI.

关 键 词：弓形虫感染 单核细胞趋化蛋白-1 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]