FCGR2A,FCGR3A基因多态性与吉兰-巴林综合征患者易感性及严重程度的关联研究  

The Association Between the Polymorphism of the FcrR Genotype and Guillain-barre Syndrome

作　　者：王雪婷[1] 韩辉[1] 戴亚美[1] 王德生[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2007年第11期809-812,共4页Heilongjiang Medical Journal

摘　　要：目的探讨FCGR2A(编码Fcγ受体Ⅱa或Fcγ受体Ⅱa基因),FCGR3A(编码Fcγ受体Ⅲa或Fcγ受体Ⅲa基因)多态性与Guillain-Barre(GBS)易感性及严重程度的相关性。方法采用序列特异性引物多聚酶链反应(PCR-SSP),对64例GBS患者(包括轻型26例,非轻型38例)及69例健康对照者的FCGR2A-131和FCGF3A-158基因多态性进行检测,比较各组间基因分布及等位基因频率的差异。结果经比较FCGR2A,FCGR3A的基因型分布,等位基因频率在患者组和非患者组以及在轻型,非轻型GBS和正常对照中均无显著性差异(P>0.05)。结论FCGF2A-131,FCGR3A-158基因多态性与GBS易感性及严重程度无相关性。Objective To investigate the polymorphism of the FcrR genotype and its association with the susceptibility of Guillian- barre Sydrome. Methods DNA of white blood cells from 64 subjects with GBS （including 26 mildly affected patients and 38 ventilated patients） and 69 healthy controls were extracted. Polymorphisms in Fcr receptor 11 A gene clusterand Fcr receptor FCGR2A - 131 was 7.7% ,69.2% and 23.1% in mildly affected patients, 10.5% ,63.2% and 26.3% in ventilated patients and 18.8% ,58.0% and 23.2% in controls （ P 〉 0.05）. The allele frequency of FC-GR2A - 131 was H131 42.3% ,R131 57.7% in mildly affected patients, H131 42.1% ,R131 57.9% in ventilated patients and,H131 47.8%,R131 52.2% in controls（ P 〉 0.05）.The genotype （W, VF and FF） distribution of FC- GR3A - 158 was 7.7% ,76.9% and 15.4% in mildly patients,5.3% ,78.9% and 15.8% in ventilated patients and 13.0% ,81.2% and 5.8% in controls （ P 〉 0.05） .The allele frequency of FCGR3A- 158 was V158 46.2% ,F158 53.8% in mildly patients, V158 44.7%, F158 55.3% in ventilated patients and V158 53.6%, F158 46.4% in con- trois （ P 〉 0.05）. Conclusion The polymorphisms of FCGR2A- 131, FCGR3A- 158 were not significantly associated with the susceptibility Guilliain-barre syndrome.

关 键 词：FCGR2A(Fcγ受体Ⅱa基因) FCGR3A(Fcγ受体Ⅲa基因) 吉兰-巴林基因多态性 

分 类 号：R745.4[医药卫生—神经病学与精神病学]