癌基因c-myc在涎腺肿瘤中的表达研究  

Significance and Expression of Oncogene c-myc in Human Salivary Gland Tumours

作　　者：郑新 黄湛[2] 李晓刚[2] 

机构地区：[1]哈尔滨第三发电公司医院口腔科,黑龙江哈尔滨150001 [2]哈尔滨医科大学第一临床院学口腔颌面外科,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2007年第11期831-833,共3页Heilongjiang Medical Journal

摘　　要：目的探讨癌基因c-myc在涎腺良恶性肿瘤中的表达及其意义。方法用免疫组化方法研究了本校病理科存档40例涎腺良恶性肿瘤石蜡标本。结果良性肿瘤呈阴性或弱阳性表达,高度恶性肿瘤呈阳性或强阳性表达,其差异具有显著性(P<0.05)。结论c-myc表达与涎腺肿瘤细胞增殖加快和分化突变有关。Objective To explore the expression and distribution of oncogene c - myc in human salivary gland tumours. Methods 40 cases of salivary gland tumours were studied using immunohistochemistry methods. Results the overexpression of c - myc were seen in all nmlignant salivary gland tumours while lightly positive or even negative expression was seen in benign ones（ P 〈 0.05）. Conclusion The expression of oncegene c - myc had some relation to the proliferation and differentiation of salivary gland tumors.

关 键 词：C-MYC癌基因 涎腺肿瘤 细胞增殖 

分 类 号：R739.8[医药卫生—肿瘤]