大蒜油及其包合物小肠吸收的研究  

The absorption study of garlic oil and it's inclusion compound in small intestine of rats

作　　者：何力[1] 何进[2] 

机构地区：[1]沈阳军区总医院,沈阳110015 [2]沈阳市康乐制药厂,沈阳110015

出　　处：《药学实践杂志》1997年第3期154-157,共4页Journal of Pharmaceutical Practice

摘　　要：本文以大蒜油为测定指标，采用大鼠在体小肠回流的方法，对大蒜油及其包合物的小肠吸收情况进行对比实验。结果表明大蒜油或包合物在体小肠循环2．5h的吸收速度常数（Ka）分别为0．9665h-1和0．2568h-1，吸收半衰期（t1／2）分别为43．13min和2．65h，吸收率分别为94．87％和51．05％，包合物经小肠循环6h吸收率接近80％。吸收曲线表明，包合物比大蒜油的吸收缓慢平稳持久，病理学检查表明，包合物能明显降低大蒜油对肠道的刺激性和毒性。By the circulating in small intestine of rats, the absorbing behavior was compared between garlic oil and its inclusion compound with concentration of garlic oil as a examining index. After garlic oil and inclusion comPOund were circulated for 2. 5 hour in the intestine, their absorption speed constants(Ka) were 0. 9665h-1 and 0. 2568h-1, respectively. Absorption halflife (t1/z) were 43. 13 minutes and 2.65 hours, respectively. Absorption rates were 94.87% and 51 .05 %, respectively circulating of the compound in the intestine for 6 hours, absorption rates were about 80%. From the absorption curves, we knew that the absorption of the compound was slower, smoother and more permanent than that of garlic oil. The pathologicol findings were that inclusion compound could lower the irritation and toxicity of garlic oil to the intestine.

关 键 词：大蒜油 Β-环糊精 包合物 小肠吸收 

分 类 号：R931.71[医药卫生—生药学] R944.9[医药卫生—药学]