药物载体系统中肝靶向药物的研究与进展  

Research progress in liver targeting drug of drug carrier system

作　　者：于雷[1] 牛俊奇[1] 

机构地区：[1]吉林大学第一医院传染科,吉林省长春市130021

出　　处：《中国组织工程研究与临床康复》2007年第44期8932-8935,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：学术背景:靶向制剂是利用药物载体系统将治疗药物最大限度地运送到靶区,使治疗药物在靶区浓集,提高治疗效果。目的:总结近10年来靶向制剂在肝脏疾病中的研究进展。检索策略:应用计算机检索PUBMED 1995-01/2007-06相关文章,检索词为"liver target,drug"并限定语言种类为"English";同时检索万方数据库1995-01/2007-06相关文章,检索词为"肝,靶向制剂,药物载体",限定语言种类为中文。选择内容与肝靶向给药系统相关的文章,排除重复及陈旧文献。文献评价:初检得到92篇文献,阅读标题和摘要后筛除28篇,查找全文后保留29篇符合标准者进行综述,其中8篇涉及靶向药物机制研究,10篇涉及肝靶向药物制剂载体研究,11篇涉及不同载体的肝靶向制剂在治疗各种肝脏疾病中的应用。资料综合:肝靶向给药系统主要包括被动靶向制剂、主动靶向制剂和物理靶向制剂。被动靶向制剂主要介绍了脂质体、前体药物、纳米粒、药质体和胆酸,主动靶向制剂介绍了半乳糖受体及三硝基苯基-抗生物素蛋白链菌素介导的肝主动靶向制剂的应用,物理靶向制剂主要指磁性靶向制剂。结论:近年来各种肝靶向药物治疗肝脏疾病均取得很大进展,载体选择、运输途径、释放途径日趋多样化,但距临床应用还有一段距离。BACKGROUND： Target preparation is to transport the medicine to the target regin using carrier system to enrich the medicine so as to improve the curative effect. OBJECTIVE： To conclude the research progress in the targeted drug of drug carrier system in recent ten years. RETRIEVE STRATEGY： A computer-based online search of Pubmed was undertaken for the relevant English articles dated between January 1995 and June 2007 with the keywords of ＂liver target, drug＂. Meanwhile, Wanfang database was searched for relevant articles published in Chinese between January 1995 and June 2007 with the words of ＂liver, target, drug carrier＂. Articles about liver target and drug carrier system were selected, and repetitive studies and old articles were excluded. LITERATURE EVALUATION： Ninety-two articles were collected after the first trial, and 28 were eliminated after reading the titles and abstracts. Finally, 29 literatures were enrolled, of which 8 referred to the mechanism of targeted drug, 10 were about the liver targeted drug, and 11 were related to the application of different carriers in the treatment of various liver diseases. DATA SYNTHESIS： Liver targeted drug carriers system mainly involves passive targeted preparation, active target preparation and physical target preparation. Passive targeted preparation introduces liposome, prodrug, nanoparticle, pharmacome and cholalic acid; active target preparation introduces the application of galactose receptor and trinitrophenyl group-streptavidin mediated liver active target preparation; physical target preparation mainly refers to magnetic target preparation. CONCLUSION： Recently, the treatment of liver diseases with various liver targeted drugs has made a great progress, and carrier selection, means of transport, and release approach are tend to diversify, however, it still needs further exploration for the clinical application.

关 键 词：肝 靶向药物 载体 

分 类 号：R575[医药卫生—消化系统]