妊娠晚期胎儿眼外肌Pulley系统发育特征  

Developmental characteristics of fetal extraocular muscle Pulley in the late trimester of pregnancy

作　　者：郑荣昌[1,2] 赵堪兴[1] 孙春华[1] 林锦镛[1] 

机构地区：[1]天津医科大学,天津市眼科医院 [2]杭州师范大学医学院附属医院眼科,浙江省杭州市310016

出　　处：《中国组织工程研究与临床康复》2007年第45期9146-9148,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金项目(30371520)资助~~

摘　　要：目的:观察妊娠晚期胎儿眼外肌Pulley形态的异同点,分析人类早期眶内Pulley系统的发育特征,探讨眶内Pulley系统对人类眼球运动及双眼视发育的作用。方法:实验于2006-04/2007-04在天津市眼科研究所完成。孕龄为27周、30周、33周的新鲜胎儿尸头各1例(标本来源合法,并得到科研管理部门的批准)。取完整眼眶,整体固定,常规脱水,石蜡包埋,冠状位连续切片,Masson三染色显示胶原纤维。结果:人类早期眶内Pulley发育中LR-IO间的Pulley连接带首先被观察到有明显的带状发育;孕30周时外直肌Pulley环己较明显,外直肌与上直肌间连接带发育较好;内直肌周围己有胶原纤维环包绕;在孕33周胎儿眶内,内直肌纤维环发育较好,但内直肌与上直肌及内直肌与下直肌间的连接带仍未见明显发育。结论:人类的眼外肌周围结缔组织结构的发育具有时间与空间的顺序性。其发育顺序为颞下侧连接带开始,经外直肌Pulley环、外直肌-上直肌间连接带、上直肌Pulley环,逐渐向鼻侧发育。这提示内侧发达的纤维环及连接带可能是在生后随双眼视功能的发育而发育完善。AIM： To observe the morphologic characteristics of extraocular muscle （EOM） Pulley of foetus, analyze developmental characteristics of early intraorbital Pulley in late trimester of pregnancy and explore the functions of intraorbital Pulley in the development of ocular movement and binocular vision. METHODS： The experiment was performed at the Tianjin Eye Institute from April 2006 to April 2007. Three cadaver orbits （ages 27 weeks, 30 weeks and 33 weeks of gestation, respectively）were selected after the approval of administration of scientific research, and then were fixed in situ and dehydrated in graded solutions of alcohol and xylenens, embedded in paraffin, and serially sectioned in the coronal plane. Masson trichrome stain was used to show collagen. RESULTS： The Pulley band between lateral rectus （LR） and IO was firstly developed in late trimester of pregnancy. At 30-week gestation, the fiber ring structure encircling LR was obvious, the LR-superior rectus （SR） became obvious, and the fiber ring structure encircling medial rectus （MR） appeared. At 33-week gestation, the fiber ring structure encircling MR was well developed, while the MR-SR or MR-inferior rectus （IR） pulley band was not obvious. CONCLUSION： The development of the connective tissue structure surrounding EOM has temporal and spatial succession. The sequence of Pulley system development is initiated from infratemperal Pulley Band, and then LR Pulley ring, LR-SR Pulley band, SR Pulley ring, and finally the nasal MR-IR pulley band. The infranasal Pulley Band （MR-IR） development may be consistent with the development of human binocular vision.

关 键 词：眼外肌 滑车 发育 眼球运动 胎儿 

分 类 号：R779.7[医药卫生—眼科]