苔藓蒽噻吩-1-羧酸甲酯的合成  

Highly efficient synthesis of methyl bryoanthrathiophene-1-carboxylate

作　　者：覃容欣[1] 罗圣霖[1] 周向东[1] 

机构地区：[1]第三军医大学医学检验系药学院药物化学教研室,重庆400038

出　　处：《第三军医大学学报》2007年第22期2124-2127,共4页Journal of Third Military Medical University

基　　金：国家自然科学基金(30472078)~~

摘　　要：目的高效合成目标分子苔藓蒽噻吩-1-羧酸甲酯。方法以1,8-二羟基-9,10-蒽醌为原料,经过保护、硝化、巯代、环合和脱保护5步反应,合成目标分子。结果以45.8%的总收率合成目标分子。结论高效合成了苔藓蒽噻吩-1-羧酸甲酯。本方法具有合成路线短、选择性好和合成效率高等特点。Objective To study the synthesis of methyl bryoanthrathiophene-1-carboxylate with high efficiency. Methods Target compounds were synthesized from 1,8-dihydroxy-9,10-anthraquinone via 5 steps including protecting, nitration, methyl mercaptoacetate substitution, intramolecular Aldol reaction and deprotecting. Results Target molecule was synthesized in the total yield of 45.8%. Conclusion Our synthesis of methyl bryoanthrathiophene-1-carboxylate is characterized by short synthetic route, high selectivity and high efficiency.

关 键 词：苔藓蒽噻吩 苔藓蒽噻吩-1-羧酸甲酯 1 8-二羟基-9 10-蒽醌 区域选择性硝化 

分 类 号：R914[医药卫生—药物化学]