食管癌切除术后炎症反应的研究  

The study of sirs after esophageal carcinoma resection

作　　者：蔡华荣[1] 张在空[1] 

机构地区：[1]重庆市肿瘤研究所,重庆400030

出　　处：《重庆医科大学学报》2007年第12期1308-1310,共3页Journal of Chongqing Medical University

摘　　要：目的:研究食管癌切除术后炎症介质IL-6、IL-8、TNF-a、中性粒细胞计数的变化。方法:选择拟行经左胸食管癌切除术的食管癌病例40例,存全麻双腔气管插管下经左胸行食管癌切除胃食管机械吻合术,术中左肺萎陷。分别于术前(T0),左肺恢复通气后(T1),术后6h(T2),12h(T3),24h(T4)采集外周血测定IL-6、IL-8、TNF-a、中性粒细胞计数。结果:外周血IL-6、IL-8、TNF-a、中性粒细胞计数在T1,T2,T3,T4时点均较T0升高。结论:开胸行食管癌切除术可引起炎症因子的升高。Objective：To study the level of IL-6,IL-8,TNF-α, neutrality granulocytic cell after esophageal carcinoma resection. Methods：40 cases,planned for esophageal cancer resection through left thoracotomy were selected. The surgery was under double lumen tracheal intubation,left thoracotomy and left lung collapse during operations.The hlood sample （for IL-6,IL-8, TNF-α,neutrality granulocytic cell）were collected at the following time points：1.preoperative （TO）. 2.After the left lung re-ventilation（T 1 ） 3.6th（T2）, 12th（T3 ）, 24th（T4） hour post-operation. Result ：The IL-6, IL-8, TNF-α, neutrality granulocytic cell level after operation were significant increased at the time point of T1 ,T2,T3,T4 compared with TO. Conclusion：The resection of esophageal cancer may heighten the inflammatory factor level.

关 键 词：开胸术 食管癌切除术 炎症因子 肺损伤 

分 类 号：R735.1[医药卫生—肿瘤] R619.3[医药卫生—临床医学]