脑星形细胞肿瘤微血管密度和NET-1蛋白的表达及其相关性  

Relationship between Microvessel Density and Expression of NET-1 Protein in Astrocytomas

作　　者：曹晓蕾[1] 陈莉[1] 陆鹏[1] 

机构地区：[1]江苏南通大学医学院病理教研室,226001

出　　处：《肿瘤防治研究》2007年第11期839-841,894,共4页Cancer Research on Prevention and Treatment

摘　　要：目的探讨脑星形细胞肿瘤组织中微血管密度(MVD)和NET-1蛋白表达的意义。方法应用免疫组化方法,检测65例脑星形细胞肿瘤组织和5例正常脑组织中,NET-1蛋白的表达以及血管内皮细胞表面抗原CD34单抗标记测定MVD,分析NET-1蛋白表达和MVD与脑星形细胞肿瘤分级关系。结果MVD与脑星形细胞肿瘤分级相关,NET-1阳性组MVD显著高于NET-1阴性组,NET-1表达强度与MVD呈高度正相关(rs=0.6682,P<0.05)。结论MVD可以是判断星形细胞瘤恶性程度指标之一,NET-1可能通过促进星形细胞肿瘤组织微血管形成发挥作用。Objective To investigate the relationships between the expression of NET-1 protein and the microvessel density in astrocytomas. Methods The expression of NET-1 protein and MVD marked with CD34 in 65 astrocytomas was examined by immunohistrochemistry SP method. The association between them and the relationship with pathologic classification were studied. Results MVI） was correlated with pathologic classification. MVI） in NET-1 positive group was higher than it in the negative group. The expression of NET-1 protein and MVD was highly correlated（r, = 0. 6682, P〈0. 05）. Conclusion MVD maybe used as an indicator of determining malignant degree in astrocytomas. NET-1 might promote the forming of microvessel density in astrocytomas.

关 键 词：脑星形细胞肿瘤 NET-1蛋白 微血管密度 CD34 

分 类 号：R730.264[医药卫生—肿瘤] R739.41[医药卫生—临床医学]