plexin-B1在乳腺癌组织中的表达及其与淋巴道转移的关系  

Expression of plexin-B1 in Human Breast Cancer and Its Relationship with Tumor Lymphatic Metastasis

作　　者：叶双梅[1] 魏军成 吴明富[1] 周丽[1] 游岚英[1] 陈颖[1] 徐刚[1] 卢运萍[1] 王世宣[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《肿瘤防治研究》2007年第11期848-851,895,共5页Cancer Research on Prevention and Treatment

基　　金：湖北省卫生厅科研基金重点资助项目(JX3A10)

摘　　要：目的探讨plexin-B1在乳腺癌组织中的表达及其与乳腺癌侵袭、转移的关系。方法应用免疫组化supervision法分别检测15例正常乳腺组织和85例乳腺癌组织中plexin-B1的表达。结果plexin-B1在正常乳腺组织中均为阴性表达,在乳腺癌组织中癌细胞和管腔内皮细胞的表达阳性率分别为76.5%(65/85)和70.6%(60/85),其中在有淋巴结转移组分别为87.0%(47/54)和85.2%(46/54),在无淋巴结转移组分别为58.1%(18/31)和45.2%(14/31),两组间的差异有统计学意义(P<0.001)。plexin-B1在乳腺癌组织中表达与雌激素受体(estrogen receptor,ER)的状态高度相关,在肿瘤细胞与淋巴管内皮细胞的表达呈显著的正相关(r=0.666,P<0.01))。但其表达与肿瘤大小、临床分期及淋巴结转移数目无关。结论乳腺癌组织中plexin-B1的高表达可能与乳腺癌发生及淋巴道转移密切相关。Objective To explore the correlation between expression of plexin-B1 and metastasis of human breast cancer. Methods Expression levels of plexin-B1 were examined in 15 normal breast specimens and 85 surgically resected breast cancer specimens by supervision immunohistochemistry. Results The expression of plexin BI in 15 normal breast specimens was completely negative. In breast cancer specimens the expression rates of plexin-B1 were 76. 5~/00（65/85）in the carcinoma nests cells and 70. 6%（60/85）in lymphatic endothelial cells respectively. The percentage of plexin-B1 positive cells was significantly higher in carcinoma nests of tumors with metastasis （87. 0%, 47/54） than those without （58. 1%, 18/31 ）, as well as in lymphatic endothelial cells with （85. 2%, 46/54） than those without metastasis （45. 2%, 14/31）. The expression of plexin-B1 is strongly correlated with the ER status. Significant positive correlation（r = 0. 666, P〈0. 01 ）of the plexin-B1 expression was found between carcinoma cells and lymphatic endothelial cells. No significant correlation was found between plexin-B1 expression level and tumor size or positive lymph nodes or tumor stage. Conclusion The high expression of plexin-Bl may be strongly correlated with the process of breast cancer progression and metastasis

关 键 词：乳腺癌 plexin-B1 肿瘤转移 淋巴管内皮细胞 

分 类 号：R737.9[医药卫生—肿瘤]