KAI1、MMP-9蛋白表达与胃癌浸润转移的关系  

Expression of KAI1 and MMP-9 Protein and Its Relationship with Invasion and Metastasis of Gastric Carcinoma

作　　者：胡艳玲 杨桂芳[2] 张红菊[2] 刘欢[2] 

机构地区：[1]湖北京山县人民医院病理科,431800 [2]武汉大学中南医院病理科

出　　处：《肿瘤防治研究》2007年第11期855-857,共3页Cancer Research on Prevention and Treatment

基　　金：湖北省自然科学基金资助项目(2003ABA185)

摘　　要：目的研究胃癌组织中KAI1、MMP-9蛋白表达,探讨它们在胃癌侵袭转移过程中的作用。方法在71例胃癌组织及20例正常胃粘膜组织中,应用免疫组织化学SP法检测KAI1、MMP-9的蛋白表达,进而分析它们彼此之间的关系及与胃癌临床病理特征之间的关系。结果KAI1、MMP-9在胃癌中的表达率分别为36.6%、67.6%,而20例正常胃组织中KAI1与MMP-9的阳性表达率分别为90%、45%,两组间差异有统计学意义(P<0.05);KAI1与MMP-9的表达均与浸润深度、淋巴结转移密切相关(P<0.05),此外,KAI1的表达还与TNM分期有关(P<0.05)。经统计分析KAI1与MMP-9呈负相关。结论KAI1、MMP-9与胃癌的侵袭转移密切相关,可作为评价胃癌的进展与预后的有力指标;KAI1、MMP-9可能通过影响血管生成参与胃癌的进展过程,为临床针对胃癌的抗血管治疗提供了新的思路。Objective To study the expressions of KAI1 and MMP-9 protein in gastric carcinoma and explore their roles in the invasion and metastasis of gastric carcinoma. Methods The expression of KAI1 and MMP-9 were detected by irnmunohistochemistry in 71 specimens of gastric carcinoma tissues and 20 specimens of normal gastric mucosa cases. Results The positive rates of KAI1, MMP-9 in gastric carcinoma tissues were 36.6%, 67.6% respectively, the expressions of K.AI1 and MMP-9 were both correlated with depth of invasion and lymph node metastasis, KAI1 was correlated with TNM stage too; By sta- tistic analysis, the expression of KAI1 and MMP-9 is of negative correlation. Conclusion The expressions of KAI1 ,MMP-9 were significantly correlated with biological behaviors of gastric carcinoma, may become target of prognostic marker in human gastric carcinoma.

关 键 词：胃癌 免疫组织化学 KAI1 MMP-9 

分 类 号：R735.2[医药卫生—肿瘤]