补肾健脾化瘀法增强rHuEPO治疗肿瘤化疗后贫血疗效研究  

Study of rHuEPO Combined with Bushen Jianpi Huayu Recipe in Treating Chemotherapy-induced Anemia Patients

作　　者：陆崇[1] 刘魁凤[1] 曾小烈[1] 温宗秋[1] 舒阳春[1] 莫贤毅[1] 丁颖[1] 

机构地区：[1]广东药学院附属第一医院肿瘤科,广州510080

出　　处：《现代生物医学进展》2007年第12期1853-1855,共3页Progress in Modern Biomedicine

摘　　要：目的:观察补肾健脾化瘀法联合基因重组的促红细胞生成素(rHuEPO)治疗中晚期恶性肿瘤化疗相关性贫血的临床疗效,以寻找进一步提高常规剂量的rHuEPO治疗恶性肿瘤贫血疗效的方法。方法:采用前瞻、随机、对照研究,将55例气血两虚型的恶性肿瘤化疗后贫血患者,随机分为研究组(A组)和对照组(B组),研究组给予补肾健脾方联合常规剂量的rHuEPO,对照组仅给予常规剂量的rHuEPO。记录治疗前及治疗后14日、28日、42日、56日时的血红蛋白(Hb)值,观察患者生活质量(QOL)改善情况和不良反应情况。结果:研究组与对照组患者的治疗后Hb、QOL与治疗前相比均有上升,研究组治疗贫血的有效率69.23%,而对照组为41.38%,两组疗效有统计学差异(X^2=4.29,p=0.04);发生促红细胞生成素抵抗的比例研究组与对照组有差异(P<0.05),并且在神疲气短、头晕眼花、纳呆消瘦等症状改善方面,研究组与对照组比较,更有优势,差异有统计学意义(P<0.05)。结论:健脾补肾化瘀法联合常规剂量的rHuEPO与单用rHuEPO相比,治疗气血两虚血瘀型恶性肿瘤患者化疗后贫血的疗效有进一步提高,发生促红细胞生成素抵抗的比例较低,且贫血症状改善更明显(P<0.05);表现出中医药疗法的优势,为化疗按时进行提供保障。Objective： To investigate the efficacy of rHuEPO combined with Bushen Jianpi Huayu Recipe on treating chemotherapy-induced anemia patients with advanced cancer, to find an inexpensive and effective method to resolve the problem--Erythropoietin resistance, and increase patients＇ hemoglobin （Hg）, the quality of life and improve symptoms of anemia. Methods： A prospective, randomized and control trial was carried out in 55 cases with advanced cancer, including lung cancer, breast cancer, rectal and colon cancer, and so on. These cases were divided into two groups： Group A was given Chinese herbs medicine （the method of invigorating the spleen, nourishing the kidney and activating blood to resolve stasis） and western medicine （rHuEPO）; Group B, only western medicine （rHuEPO）. The values of haemoglobin before treatment and 12, 28, 42, 56 hours after treatment were recorded, and the quality of life（QOL） and untoward effects were observed. Results： The level of hemoglobin in Group A was higher than that of Group B, The effective rate of treating anemia of Group A was 69.23%, while that of Group B was 41.38% （X2-4.29, p=0.04）. Group A was better than group B in the rate of Erythropoietin resistance, and in improvement of symptoms such as short breath, daze, fatigue. Conclusions： Jianpi Bushen Huayu Recipe combined with conventional dose of rHuEPO is superior to only rHuEPO in treating the chemotherapy-induced anemia patients with advanced cancer, which shows the predominance of Chinese and western medcinal therapyand offers the guarantee for timely per- formance of patients＇ chemotherapy.

关 键 词：促红细胞生成素抵抗 贫血 恶性肿瘤 中西医结合治疗 

分 类 号：R730.53[医药卫生—肿瘤] R289.5[医药卫生—临床医学]