血清新蝶呤与动脉粥样硬化性血栓性脑梗死的相关性  

Relationship Between Serum Neopterin Level and Atherosclerosis Thrombotic Cerebral Infarction

作　　者：李玉云[1] 李颖[2] 宋本华[1] 

机构地区：[1]齐齐哈尔市第一医院神经内科,黑龙江省齐齐哈尔市161005 [2]哈尔滨医科大学附属第二医院老年病科,黑龙江省哈尔滨市150086

出　　处：《中国动脉硬化杂志》2007年第8期641-643,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨新蝶呤与动脉粥样硬化性血栓性脑梗死发病机制的可能关系。方法对50例动脉粥样硬化性血栓性脑梗死急性期患者和50例健康体检者分别测定了外周静脉血清新蝶呤水平。结果动脉粥样硬化性血栓性脑梗死急性期患者外周静脉血清新蝶呤水平显著高于正常人(5.07±1.70μg/L比2.04±0.21μg/L,P<0.05)。结论在动脉粥样硬化性血栓性脑梗死患者中新蝶呤水平显著升高,免疫激活可能参与了动脉粥样硬化性血栓性脑梗死急性期的病理生理过程,新蝶呤是动脉粥样硬化性血栓性脑梗死活动的一个重要指标。Aim To explore relationship between the serum neopterin level and atheroselerosis thrombotic cerebral infarction （ATCI）. Methods The neoptefin of peripheral vein were measured in 50 cases of aeute stage of ATCI and 50 cases of healthy controls. Results The levels of neoptefin of peripheral vein in acute stage of ATCI group were significantly higher than those in healthy controls （ 5.07 ± 1.70 μg/L vs 2 . 04 ± 0 . 21 μg/L, P〈0.05）. Conclusion The levels of neopterin were significantly elevated in patients with ATCI, immune activition probably participated in course of pathophysiology of acute stage of ATCI, and neoptefin was an important mark of the activity of ATCI.

关 键 词：神经病学 动脉粥样硬化 血栓 脑梗死 新蝶呤 

分 类 号：R741[医药卫生—神经病学与精神病学]