叶黄素改善老龄大鼠抗氧化功能的研究  

Effects of Lutein on Antioxidantive Action in Aged Rat

作　　者：裴凌鹏[1] 惠伯棣 董福慧[1] 

机构地区：[1]中国中医科学院骨伤科研究所,北京100700 [2]生物活性物质与功能食品北京市重点实验室,北京100083

出　　处：《中央民族大学学报（自然科学版）》2007年第3期197-201,205,共6页Journal of Minzu University of China(Natural Sciences Edition)

基　　金：国家自然科学基金(项目号:30171169);生物活性物质与功能食品北京重点实验室开放课题(ws-01)

摘　　要：用D-半乳糖注射Wister雄性大鼠5个月,建立衰老模型.对模型组、药物组血清MDA含量、肝脏匀浆MDA含量和血液SOD、GSH-Px酶活性进行测定及比较.实验结果表明药物组血清MDA含量和肝脏匀浆MDA含量均比模型组有显著降低(P<0.01),而血液SOD、GSH-Px酶活性比模型组有显著升高(P<0.01).因此摄入适量叶黄素可以有效地增强大鼠机体抗氧化能力,从而延缓D-半乳糖诱发的大鼠衰老.To cause aging, Wistar rats were given injections of D-galactose for 5 months. They were randomly divided in four groups, including model group, low - medication group, middle-medication group and high - medication group whose the content of serum MDA, liver MDA and the activity of SOD and GSH-Px were tested and compared. Experimental results showed that the content of serum MDA, liver MDA in the medication group were significantly decreased （ P 〈 0.01 ）, compared with model group. However, the activity of SOD and GSH-Px was significantly raised（ P 〈 0.01）. Therefore lutein can increase antioxidantive function of rat to stay D-galactose induced consenescence.

关 键 词：丙二醛 超氧化物歧化酶 谷胱甘肽过氧化酶 叶黄素 

分 类 号：Q946[生物学—植物学]