热疗联合放疗治疗老龄贲门癌33例  

Efficacy of combined radiation and hyperthermia for cardiac carcinoma in older patients:an analysis of 33 cases

作　　者：周健[1] 卢绪菁[1] 

机构地区：[1]苏州大学附属常州肿瘤医院放疗科,江苏省常州市213001

出　　处：《世界华人消化杂志》2007年第29期3127-3130,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨热放疗治疗老年贲门癌的临床疗效方法:将64例老龄贲门癌患者随机分为两组.单纯放疗组31例,热放疗组(热疗加放疗)33例.放疗采用6-15 MVX线常规照射DT 60—66 Gy,6-6.5 W.热疗于放疗后1h内开始,应用HG2000体外高频热疗机治疗,频率13.56 MHz,电极直径17-21 cm,置于上腹部前后,局部温度40℃-43℃,每次40 min,2次/wk,共10次.结果:单纯放疗组与热放疗组近期疗效CR(25.81% vs 42.42%),PR(41.94% vs 48.48%)和有效率(67.74% vs 90.91%)相比均有显著性意义(P=0.046,x^2=3.966);单纯放疗组和热放疗组1、2、3年生存率(58.06% vs 72.72%,38.71% vs 51.51%,19-35% vs 33.33%)和中位生存期(15 mo-27 mo)远期疗效相比也有显著意义(P=0.018,x^2=5.588).除热放疗组有3例出现皮下硬节,余治疗反应两组无明显差别,均未出现消化道溃疡、穿孔、出血等严重不良反应.结论:热放疗对老年贲门癌患者的疗效优于单纯放疗,且不增加副反应,可以提高局部控制率,从而延长生存期.AIM： To evaluate the radiotherapy for older carcinoma. efficacy of thermopatients with cardiac METHODS： Sixty-four older patients with cardiac carcinoma were randomly divided into two groups, among which 31 were treated with simple radiotherapy and 33 with thermo-radiotherapy. Both groups received normal irradiation of 60-66 Gy/6-6.5 W. For the combination group, heating was administered within 1 hour after completion of radiation, with local temperature ranging from 40 to 43℃. Each session took 40 min and two sessions were given every week. Ten sessions in total were given. RESULTS： For the simple radiotherapy group, the complete response rate was 25.81%, total response rate was 67.74%, and 1-, 2- and 3-yearsurvival rates were 58.06%, 38.71% and 19.35% respectively, with a median survival time of 15 mo. In the thermo-radiotherapy group, the complete response rate was 42.42%, total response rate was 90.91%, and the 1-, 2- and 3 years survival rates were 72.72%, 51.51% and 33.33%,respectively, with a median survival time of 27 months. A significant difference was observed between the two groups （P 〈 0.05）. Side effects of radiotherapy were not different between the two groups. Fatty nodules were found in three patients in the thermo-radiotherapy group. CONCLUSION： The efficacy of thermo-radiotherapy is greater than that of simple radiotherapy for older patients suffering from cardiac cancer. It can prolong survival time by improving local control rate without increasing adverse effects.

关 键 词：贲门肿瘤/放射疗法 热疗 高龄 

分 类 号：R735.2[医药卫生—肿瘤]