Mcl-1蛋白在宫颈病变中的表达及意义  

Expression of Mcl-1 protein in human cervical lesions and its significance

作　　者：胡轶[1] 田媛[1] 吴鹏[1] 周剑峰[2] 马丁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030 [2]华中科技大学同济医学院附属同济医院血液科,武汉430030

出　　处：《肿瘤》2007年第11期899-901,共3页Tumor

基　　金：国家自然科学基金资助项目(编号:30371657);国家重大基础研究资助项目(编号:2002CB513107)

摘　　要：目的:髓样细胞白血病-1(myeloid cell leukemia-1,Mcl-1)蛋白是bcl-2家族成员,它在调控肿瘤细胞的凋亡?增殖?分化等过程中起一定作用。本研究拟检测子宫颈病变组织中Mcl-1蛋白的表达,探讨该蛋白在宫颈癌形成和演进进程中的意义。方法:采用免疫组织化学SP法检测83例石蜡包埋的子宫颈组织中Mcl-1的表达情况,并结合临床病理分型分析其表达的意义。结果:Mcl-1蛋白在慢性宫颈炎、宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CIN)和宫颈癌组织中的阳性率分别为4.0%,33.3%和74.2%,3组样本中Mcl-1的阳性率差异有统计学意义(P<0.05),宫颈癌病理学分级G1及G2期与G3相比,差异有统计学意义(P<0.05)。Mcl-1蛋白表达阳性率与CIN的分级、与宫颈癌临床分期、组织学分型和淋巴结转移无关(P>0.05)。结论:Mcl-1蛋白在宫颈癌组织中表达升高,可能在宫颈癌的发生发展过程中起重要作用。Objective： Myeloid cell leukemia-1 （ Mcl-1 ） protein is one of the numbers in bcl-2 superfamily, which plays an important role in controlling apoptosis, proliferation, and differentiation of tumor cells. This study was to detect the expression of Mcl-1 protein in different stages of human cervical lesions and to explore further their possible roles in the formation and progression of cervical cancer. Methods： The expression of Mcl-1 protein was detected in 83 paraffin-embedded specimens of the cervical tissues with immunohistochemical SP methods. Its clinical significance was analyzed associating with clinicopathological classification. Results： The positive rate of Mcl-1 protein expression was 4.0%, 33.3%, and 74.2% in cervicitis, cervical intraepithelial neoplasia （CIN） and cervical cancer tissue, respectively. The difference was significant among the three groups （P 〈 0.05 ）. The positive rate of Mcl-1 protein expression was significantly, different between G1 ＋ G2 and G3 cervical cancer （P 〈 0.05 ）. The positive expression of Mcl-1 in cervical cancer had no association with CIN grade, FIGO stage, histological type, and lymph node metastasis （P 〉 0.05 ）. Conclusion： Over-expression of Mcl-1 may play an important role in the initiation and development of cervical cancer.

关 键 词：宫颈肿瘤 髓样细胞白血病-1基因 基因表达 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]