^(125)I内放疗联合热疗和化疗治疗中晚期肿瘤的临床观察  

Clinical observation on ^(125)I seed brachytherapy combined with chemotherapy and thermotherapy for mid-advanced tumor

作　　者：张智勇[1] 李珂[1] 刘立祥[1] 丁昌利[1] 郑盈[1] 刘莉[1] 陆震宇[1] 

机构地区：[1]上海市第一人民医院分院肿瘤科,上海200081

出　　处：《肿瘤》2007年第11期914-916,共3页Tumor

摘　　要：目的:探讨125I粒子内放疗联合热疗和化疗治疗中晚期肿瘤的临床价值。方法:回顾性总结分析22例中晚期肿瘤病人125I粒子植入联合化疗、热疗的方法和经验。采用手术或CT引导下植入(1.48~2.59)×107Bq125I粒子,26处病灶共445个粒子。术后联合化疗和热疗,随访血象、免疫学指标、肿瘤学指标、影像学改变等,评价近期疗效。结果:术后3个月复查,肿瘤学指标显著下降。全组患者CR 5例,PR 12例,NC 2例,PD 3例,客观有效率为77.3%(17/22),局部病灶控制率95.5%(21/22)。1例肺癌患者植入粒子过程中出现气胸。1例患者出现粒子移位(肺内)。未见其他严重并发症。结论:125I放射性粒子植入联合化疗和热疗治疗中晚期肿瘤近期临床效果良好,并发症发生率低,是综合治疗中晚期肿瘤的一种简单、安全、有效的方法。Objective： To investigate the clinical value of brachytherapy with radioactive ^125I seed implantation combined with chemotherapy and thermotherapy for mid-advanced tumor. Methods： Twenty two patients with mid-advanced tumor were implantated radioactive ^125I seed followed by chemotherapy and thermotherapy. Their clinical data was retrospectively reviewed and analyzed. Total 445 ^125I seeds of （1.48-2.59） × 10^7 Bq were implanted into 26 foci with the guidance of surgery or CT. Combined chemotherapy and thermotherapy was performed after brachytherapy. All the patients were followed up. The blood biochemical index, immune function, and biological parameters of oncology and imaging changes were measured. The short-term efficacy was evaluated. Results： The oncological parameters significantly decreased 3 months after operations. There were 5 patients with complete response （CR）, 12 with partial response （PR）, 2 with no change （NC）, 3 with progressive disease （PD）. The objective response rate was 77.3% （17/22）. Local foci control rate was 95.5% （21/22）. One patient had pneumothorax during ^125I seed implantation and the other patient had seeds migration in lung. No other severe complications were observed. Conclusion： Radioactive ^125I seed implantation combined with chemotherapy and thermotherapy has good clinical effects in treating mid-advanced tumor with low occurrence of complications. It is a simple, safe, and effective method for combined treatment of mid-advanced tumor.

关 键 词：肿瘤 近距离放射疗法 高温 诱发 药物疗法 综合疗法 

分 类 号：R730.58[医药卫生—肿瘤]