男性原发无(少)精子症Y染色体微缺失的筛查研究  

Screening Study on Y-chromosome Microdeletion in Males with Idiopathic Azoospermia and Oligospermia

作　　者：李聪敏 薄立伟 郝戈芳 

机构地区：[1]河南省人口和计划生育科研院,郑州450002

出　　处：《中国计划生育学杂志》2007年第11期682-684,共3页Chinese Journal of Family Planning

摘　　要：目的:探讨男性原发无精子症和少精子症与Y染色体无精子症因子(AZF)微缺失的关系。方法:应用多重PCR技术对原发无精子症(24例)和少精子症(19例)患者基因组DNA进行Y染色体连锁的6个序列标签位点缺失分析。结果:43例患者中检出有Y染色体微缺失4例,缺失率为9.3%,其中无精子症3例,少精子症1例。结论:Y染色体微缺失是原发无精子症和少精子症的重要原因之一,对原发无精子症和少精子症患者进行Y染色体微缺失的常规筛查是有必要的。Objective： To evaluate the relationship between Y chromosome azoospermia factor（AZF） microdeletion and idiopathic azoospermia/oligospermia in males. Methods： Multiplex PCR was used to detect Y chromosome deletion in 43 idiopathic azoospermia/oligospermia patients （24 idiopathic azoospermia patients, 19 idiopathic oligospermia patients）. Results： Y chromosome AZF microdeletion was found in 4 patients and the rate of deletions was 9.3%. Among the 4 cases, 3 cases were with azoospermia and 1 case was with oligospermia. Conclusion ： Y chromosome deletion is one of the important factors of idiopathic azoospermia/oligospermia. It is necessary to carry out the routine screening of Y chiromosome microdeletion to the idiopathic azoospermia/oligoseprmia patients

关 键 词：原发无精子症 原发少精子症 无精子症因子 微缺失 

分 类 号：R698.2[医药卫生—泌尿科学]