DNA修复基因单核苷酸多态性预测铂类药物敏感性和预后  

Polymorphisms of DNA repair genes are predictive factors for the tumor response and prognosis to platinum chemotherapy

作　　者：方桦[1] 王兴元[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院内科,北京100021

出　　处：《癌症进展》2007年第6期561-566,共6页Oncology Progress

摘　　要：铂类药物是治疗实体肿瘤常用的药物之一,但是肿瘤细胞对铂类药物耐药导致化疗失败,成为临床治疗的一大难题。DNA修复能力是影响疗效的重要原因。DNA修复基因单核苷酸多态性(SNP)可改变DNA修复能力,因此,检测这些基因的单核苷酸多态性可以预测疗效。现综述DNA修复基因单核苷酸多态性预测铂类药物敏感性和预后的研究进展。Platium-based doubets are one of the most common regiments for solid tumors. However, it is difficult to identify platinum resistance in clinical treatment. DNA repair capacity is a predictive factor for tumor response and prognosis. Since single nucleotide polymorphisms （SNPs） of DNA repair genes can affect DNA repair capacity, SNPs in DNA repair genes may provide a noninvasive approach to predict treatment response and prognosis.

关 键 词：DNA修复 多态性 铂类药物 化疗敏感性 

分 类 号：R730.1[医药卫生—肿瘤]