腹腔镜手术后直肠癌患者生活质量评价  

Quality of life in patients with rectal cancer after laparoscopic colectomy

作　　者：李军[1] 丁克峰[1] 王晓晨[1] 孙立峰[1] 王建伟[1] 张苏展[1] 

机构地区：[1]浙江大学医学院附属第二医院,浙江杭州310009

出　　处：《浙江大学学报（医学版）》2007年第4期371-377,共7页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省自然科学基金资助项目(X206953)

摘　　要：目的:评价腹腔镜手术后直肠癌患者生活质量。方法:本研究是前瞻性非随机观察研究。2004年9月至2005年12月间共51位直肠癌患者加入研究并接受了手术治疗,其中腹腔镜手术组23人,开腹手术组28人。以EORTC QLQ-C30和QLQ-CR38量表测定患者术前、出院时和术后3个月时的生活质量。结果:术前腹腔镜组患者角色功能(Role functioning)低于开腹组患者,但是腹腔镜组患者较少有经济困难,差异有统计学意义(P<0.05),但是没有临床意义。两组患者其余各领域评分均无差异(P>0.05)。两组患者术后各领域评分相当(P>0.05)。腹腔镜手术组患者只是在出院时的疼痛轻于开腹手术组患者,差异有统计学意义(U=218.5,P=0.042),但是没有临床意义。结论:与开腹手术比较,直肠癌腹腔镜手术只在术后短期内显示了有限的优势。腹腔镜手术对直肠癌患者生活质量影响的评价有待于进一步研究。Objective： To assess the quality of life in patients with rectal cancer after laparoscopic colectomy. Methods： From Sep. 2004 to Dec. 2005,51 patients with rectal cancer were recruited in this prospective, non-randomized study. Twenty-three patients underwent laparoscopic colectomy （LC） ,28 patients had open colectomy （OC）. EORTC QLQ-C30 and QLQ- CR38 questionnaire were applied to evaluate quality of life baseline,discharging and 3 months after operation. Results： Before operation,the median score of role functioning in LC group was lower. However,LC group patients complained less financial difficulties. The differences were of statistical significance （P〈 0. 05）, hut not of clinical significance. The median scores of other function domains and symptom domains were similar between two groups （P 〉 0. 05）. Postoperatively,the most median scores of function domains and symptom domains between two groups were similar （P〉0.05）. The only score with statistically significant difference was the pain when patients left hospital （U = 218. 5, P = 0. 042）. However, the difference was not of clinical significance, too. Conclusion： Only minimal benefits in short-term postoperative quality of life are found with laparoscopic colectomy in patients with rectal cancer compared with open colectomy.

关 键 词：结直肠肿瘤/外科学 腹腔镜检查 前瞻性研究 生活质量 

分 类 号：R735.37[医药卫生—肿瘤]