71例复发性儿童非何杰金氏淋巴瘤临床分析  

Clinical Analysis of 71 Cases of Recurrent NHL of Children

作　　者：张新华[1] 付小玉[1] 魏新林[1] 

机构地区：[1]湖北省肿瘤医院

出　　处：《河南肿瘤学杂志》1997年第3期192-193,共2页Henan Journal of Oncology

摘　　要：我院于1979～1991年收治经初治获得完全缓解而复发的儿童非何杰金氏淋巴瘤71例，均经病理证实。分期：Ⅰ期2例，Ⅱ期40例，Ⅲ期14例，Ⅳ期15例。71例中68例给予COCP/CHOP交替化疗4～8周期，3例沿用初治方案COCP化疗4周期。结果：CR34例，占47．9％，PR22例，占31．0％，有效率为78．9％，1、3、5年生存率分别为53．5％、26．8％、21．1％，再化疗疗效较好。本文且按复发时间、近期缓解度、部分临床特点分组进行了1、3、5年生存率的对比，结果表明：1年内复发患者组1、3、5年生存率分别低于1年后复发者（P＜0.05）；经再化疗获得CR组分别高于未获得CR组（P＜0．05）；无B症状组分别高于伴B症状组，但经统计学处理，P值分别＞0．05。作者认为对复发性NHL患者的治疗，应趋向于多种互不交叉耐药的化疗方案交替治疗，争取获得CR，提高生存率。From l979 to l99l, there were 7l childrin heated in our hospital who had meonnt NHL with complte regression after inihal therapy. Detendnated by histibocal eednation, the patients were classified into stagesI, Ⅱ, Ⅲ and Ⅳ with 2, 40, l4 and 15 case, respehvely, accotiling to AnnMior standard. 68 paients accepted altemative of CHOPO and CHOPO regimes for 4 ~ 8 cycles while the other 3 cases continued to use the inihal ndme of COCP for 4 cycles. The result8 showed that CR was 47.9% in 34 cases and PR was 3l .0% in 22 cases, the total effective rate was 78.9%. The l -, 3 -and 5 - year survival rates were 53. 5%, 26. 8% and 2l. l %, respectively. Based on mermnt time,degree of arent relaxaion and wial clinical chnaters, the l -, 3 - and 5 - year swhval rates were contrasted, the results showed that the group of meurmnce below one year was significanily lower than tha of meonnce after 0ne year respechvely, (P < 0. 05), the CR pop with rebeatment was higher than PR group, repehvely, (P < 0.05). The group with B Symptoms was fowr than that without B Symptoms, respectively, (P > O. 05). We concluded that for the beatment of reconnt NHL pahents,the regimes with multiple and non - cross nsistence agents should be meornded for altemaive therapy so as to ny to get CR results and elevae the ndval rate.

关 键 词：儿童 NHL 复发 再化疗 非何杰金氏 淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]