上皮型钙黏蛋白在子宫内膜异位症患者血清中的表达及意义  

The role of E-cadherin on the diagnosis and prognosis of endometriosis

作　　者：史文静[1] 宋绿茵[1] 梅开勇[1] 郑彩银[1] 郑少秋[2] 张红[2] 秦础强[2] 江敏妍[2] 江洁颖[2] 白翔[2] 

机构地区：[1]广州医学院第二附属医院妇产科,病理科,广东广州510260 [2]广州医学院第二临床学院,广东广州510260

出　　处：《中国现代医学杂志》2007年第21期2583-2585,共3页China Journal of Modern Medicine

基　　金：广州市医药卫生科技项目;编号2005-YB-138

摘　　要：目的探讨血清上皮型钙黏蛋白(E-cad)在子宫内膜异位症血清中的表达及在诊断和预后评估中的作用。方法以酶联免疫法检测不同分期和术前术后的子宫内膜异位症患者、对照组血清中E-cad的含量,并分别进行比较。结果子宫内膜异位症组血清中E-cad含量较对照组明显升高(P<0.05);Ⅲ、Ⅳ期子宫内膜异位症患者血清中E-cad水平高于Ⅰ、Ⅱ期,但差异无统计学意义(P>0.05);术后1个月血清中E-cad水平低于术前(P<0.05)。结论E-cad在内异症发病中可能起一定的作用;其血清水平在子宫内膜异位症患者明显升高,虽与疾病严重程度无关,但与预后密切相关。[Objective] To investigate the role of E-cad on the diagnosis and prognosis of endometriosis. [Meth- otis] The level of E-cad in the serum of endometfiosis patients was compared with that of the control group by using the enzyme finked immunosorbent assay. The endometriosis patients included different stages patients, preopetative and postopetative patients. [Results] The level of E-cad in serum of endometriosis patients was significantly higher than that of control group （P 〈0.05）. The level of E-cad in the serum of both Ⅲ stage and Ⅳ stage endometrlosis patients was higher than that of Ⅰ and Ⅱ stage patients. But the difference between them was not statistically significant. The level of E-cad in the serum of postopetative patients was lower than that of preopetative patients. [Con- clusions] E-cad may play a role on the morbidity of endometriosis. Though the increase of the level of E-cad in serum is independent of the severity of endometriosis, it is correlated with the prognosis of endometriosis.

关 键 词：上皮型钙黏蛋白 子宫内膜异位症 酶联免疫法 

分 类 号：R713.4[医药卫生—妇产科学]