生长抑素受体亚型在胰腺癌组织与非癌胰腺组织表达的对比研究  

Expression of somatostain receptor subtypes in human pancreatic cancer and pancreas

作　　者：何长生[1] 全竹富[1] 张新华[2] 孙桂勤[2] 李宁[1] 黎介寿[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所,江苏南京210002 [2]南京大学医学院临床学院(南京军区南京总医院)病理科,江苏南京210002

出　　处：《肠外与肠内营养》2007年第6期338-343,共6页Parenteral & Enteral Nutrition

摘　　要：目的：探讨生长抑素受体（SSTR）5种亚型在胰腺癌组织中的表达及临床意义，为临床应用生长抑素（SS）及其类似物诊断、治疗胰腺癌提供依据。方法：采用免疫组化EnVision法检测50例胰腺癌及46例非癌胰腺组织中SSTR1～5亚型的表达。结果：SSTR1～5在胰腺癌组织中均有表达，除SSTR1表达较低外，SSTR2—5均为高表达。SSTR1～5表达阳性率分别为50％、94％、82％、90％和96％；SSTR1—5在非癌胰腺组织中亦有类似表达，阳性率分别为28．3％、97．8％、67．4％、78．3％和97．8％。胰腺癌与非癌胰腺组织比较，除SSTR1表达显著高于非癌胰腺组织外（P〈0．05），SSTR2—5并无差异。结论：SSTR在胰腺癌及非癌胰腺组织均有表达，但SSTR1在胰腺癌表达阳性率显著高于非癌胰腺组织。Objective ： To explore the expression of SSTR 1, SSTR 2, SSTR 3, SSTR 4 and SSTR 5 in human pancreatic cancer and non-cancer pancreatic tissue. Methods： Immunohistochemical staining of 5 SSTR subtypes was performed by the EnVision technique for paraffin sections of 50 cases pancreatic cancer and 46 cases non-cancer pancreatic tissue. Results ： Positive staining for all 5 SSTR subtypes was observed in pancreatic cancer and non-cancer pancreatic tissues. The expression of SSTR 1 was significantly higher than non-cancer pancreatic tissues. No significant difference of SSTR 2 -5 expression was found in pancreatic cancer tissues and non-cancer pancreatic tissues. Conclusion ： The expressions of SSTR 1 -5 are detected in human pancreatic cancer and non-cancer pancreatic tissues. The expression of SSTR 1 is obviously higher than that of SSTR2 - 4.

关 键 词：生长抑素 生长抑素受体 胰腺癌 胰腺 免疫组化 

分 类 号：R735.9[医药卫生—肿瘤]