大蒜对口腔癌前病变的预防作用及其对NK,T淋巴细胞功能和IL-2影响的实验研究  

THE PREVENTING FUNCTION OF GARLIC ON EXPERIMENTAL ORAL PRECANCER AND ITS EFFECT ON NATURAL KILLER CELLS, T LYMPHOCYTES AND INTERLEUKIN 2

作　　者：唐瞻贵[1] 沈子华[1] 刘蜀凡[1] 翦新春[1] 孙科柱[2] 燕美玉[2] 何堂良 

机构地区：[1]湖南医科大学口腔医学系 [2]湖南医科大学免疫室 [3]江西鹰潭铁路医院口腔科

出　　处：《湖南医科大学学报》1997年第3期246-248,共3页Bulletin of Hunan Medical University

基　　金：湖南省科委资助

摘　　要：为探讨大蒜对口腔癌前病变的预防作用及其机制，将３２只Ｗｉｓｔａｒ大白鼠随机分为二组。大蒜组大鼠硬腭粘膜涂大蒜注射液，对照组涂等量蒸馏水；随后涂４－硝基喹啉氧化物；每周３次，共１３周。结果显示，大蒜能有效地预防口腔癌前病变发生，且提示这种预防作用与大蒜提高自然杀伤细胞活性，改善Ｔ细胞功能及提高白细胞介素－２水平有关。In order to study the effect and mechanism of garlic on preventing oral precancer, we divided randomly 32 Wistar rats into two groups. The garlic group was painted with garlic solution on the hard palatal mucosae. The control group was applied with distilled water that is equal in quantity. Then, chemical carinogen 4 nitroquinoline 1 oxide (4NQO) was painted on the same sites for both groups, three times weekly. Eight rats were randomly killed in the 10th, 13th week. The hard palatal mucosae were examined with light microscope. Meanwhile, lymphocytes were isolated from the rat spleens. The activation of natural killer (NK) cells and T lymphocytes, and level of interleukin 2 were determined by radioimmunoassay. The results revealed that garlic efffectively prevented oral precancer induced by 4NQO. This effect may be related to the following factors that garlic can improve the activation of NK cells, the function of T lymphocytes, and the level of IL 2.

关 键 词：口腔肿瘤 癌前病变 预防 大蒜 NK细胞 T细胞 

分 类 号：R739.801[医药卫生—肿瘤]