A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides  

作　　者：孙逊 朱俊 钟晨 泉铉治 张晨 

机构地区：[1]Department of Chemistry of Natural Products, School of Pharmacy, Fudan University, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2007年第12期1866-1870,共5页中国化学（英文版）

摘　　要：A new and convenient synthetic method has been developed for the construction of stilbenes bearing electron-withdrawing group（s） by using benzils and arylmethyldiphenylphosphine oxides via sequences involving Wittig-Horner reaction and a rearrangement in the presence of t-BuOK in toluene under mild conditions. This approach could be readily applied to a facile synthesis of biologically important natural products, resveratrol and its derivatives, such as trimethoxystilbenes 1 （Z） and 2 （E）.A new and convenient synthetic method has been developed for the construction of stilbenes bearing electron-withdrawing group（s） by using benzils and arylmethyldiphenylphosphine oxides via sequences involving Wittig-Horner reaction and a rearrangement in the presence of t-BuOK in toluene under mild conditions. This approach could be readily applied to a facile synthesis of biologically important natural products, resveratrol and its derivatives, such as trimethoxystilbenes 1 （Z） and 2 （E）.

关 键 词：STILBENE substituted benzil arylmethyldiphenylphosphine oxide resveratrol 

分 类 号：O6[理学—化学]