局部晚期鼻咽癌同时放、化疗疗效观察  

Clinical study of local-advanced nasopharyngeal carcinoma treated with concurrent chemotherapy and radiotherapy

作　　者：郑庆伟[1] 陈万泉[1] 

机构地区：[1]龙岩市第二医院放疗科,福建龙岩364000

出　　处：《现代肿瘤医学》2007年第12期1766-1768,共3页Journal of Modern Oncology

摘　　要：目的:观察同期放、化疗治疗局部晚期鼻咽癌的近期疗效、生存率、局部控制率、远处转移率和毒副反应。方法:60例局部晚期鼻咽癌为综合治疗组,分别在放疗第1,5周及放疗后1周给予DDP30mg/m21天～3天,5-Fu500mg/m21天～5天化疗共4～5个周期,另配对选取60例单纯放疗者为对照组,两组放疗方法相同。结果:综合组与单放组鼻咽肿瘤完全消退率分别为93%和84.2%(P>0.05),颈部淋巴结完全消退率分别为87.2%和59.8%(P<0.05),3年生存率分别为75.2%和48.3%(P<0.05),3年局控率分别为87.2%和70.3%(P<0.05),3年远处转移率分别为17.2%和38.8%(P<0.05)。综合组白细胞减少症、胃肠道反应和口腔粘膜反应较单放组多且明显(P<0.05),但可接受。结论:同期放、化疗与辅助化疗有助于提高局部控制率和生存率,减少远处转移率。Objective：To study the survival of local -advanced nasopharynjgeal carcinoma（NPC） patients treated with radiation alone and compared patients treated with chemoradiation. Methods：From February 2001 to June 2003, 60 patients with local - advanced NPC（ group A） were treated with DDP and 5 - Fu combined with simultaneous standard radiotherapy, in which DDP and 5 - Fu were intravenously given every 4 weeks for four to five courses. Another 60 patients （group B） chosen from the same period and matched with the group A by sex,age,karnofsky performance scale, and clinical stage were treated with standard radiotherapy alone. Results ： At 2 - 3 months after radiotherapy the complete response rate of the metastases of lymph nodes in group A was significantly higher than that in group B （ P 〈0. 05 ）. The tumor control rates of group A and group B at 3 - year were 87.2% to 70.3 % （ P 〈 0 05 ） respectively, and the distant metastatic rates at 3 - year were 17.2% to 38.8 % （ P 〈 0. 05 ） respectively, and the survival rate at 3 - year were 75.2% to 48.3% （P 〈0. 05 ） respectively. Conclusion： Radiotherapy combined with chemotherapy may increase the local disease control and the survival rate and may also decrease the distant metastasis in patients with local - advanced NPC.

关 键 词：鼻咽肿瘤 化学疗法 放射疗法 

分 类 号：R739.63[医药卫生—肿瘤]