早期乳癌保乳术后放射治疗的疗效观察  

Clinical outcome of conservative surgery plus radiation therapy in early stage breast cancer patients

作　　者：鞠云鹤[1] 杨毅[1] 秦继勇[1] 吴星娆[1] 

机构地区：[1]云南省肿瘤医院,云南昆明650118

出　　处：《现代肿瘤医学》2007年第12期1780-1781,共2页Journal of Modern Oncology

摘　　要：目的:观察早期乳腺癌保乳术后放射治疗的疗效。方法:对30例Ⅰ～Ⅱ期乳腺癌患者行乳腺病灶局部切除加腋窝淋巴结清扫,术后全乳腺先用6MV-X线双切线半野照射,全乳腺剂量达40Gy～52Gy(平均46Gy),然后,用9MeV或12MeV电子线局部瘤床加量8Gy～20Gy。腋窝淋巴结有转移者,用6MV-X线和12MeV电子线混合加照锁骨上和腋顶淋巴结引流区域,总剂量50Gy。结果:1年生存率为96.7%,3年生存率为90.0%,5年生存率为86.6%,中位生存率为92个月,局部复发率为0(0/30)。乳房美容评价:医生打分满意度优、中的为86.67%(26/30),患者自评满意度优、中的为93.33%(28/30)。结论:早期乳腺癌保乳术后放射治疗可降低局部复发率,减少并发症,乳房美容效果好,但必须严格掌握保乳手术适应证及综合治疗的相关技术。Objective：To evaluate the clinical outcome in early stage breast cancer patients treated with conservative surgery plus radiation therapy. Methods： Thirty patients were treated by postoperative whole -breast irradiation and a tumor bed boost from 1995 to 2005. The postoperative radiotherapy consisted of whole - breast 6MV linear accelerator irradiation with two tangential half fields to a total dose of 40 -52 Gy （mean 46 Gy） , followed by a boost irradiation to the tumor bed for 8Gy - 20 Gy. Patients with lymph metastasis received 50Gy boost at the axilla and upraclavicular. Results ：The overall 5 year survival was 86.6% ,with local recurrence of 0. No radiation - induced ulcer was observed in the breast except for acute inflammation at skin pinholes in patients treated by interstitial implant brachytherapy. Cosmetic result scored as good by patient and doctor were 93.33% and 86.6%. Condusion： Tumor bed boost irradiation by either brachytherapy or electron beam technique can provide satisfactory local control in early breast cancer treated with conservative surgery plus radiotherapy without increasing the side effects.

关 键 词：乳腺癌 保乳术 放射治疗 

分 类 号：R737.9[医药卫生—肿瘤]