格拉司琼与恩丹西酮防治食管癌术后化疗所致恶心呕吐的疗效对比  

The comparison of the preventive effect on chemotherapy-induced nausea and vomiting in post-operative esophageal carcinoma patients treated by granisetron and ondansetron

作　　者：张瑞[1] 王英禹[1] 周勇安[1] 程庆书[1] 孙晓雁[1] 

机构地区：[1]第四军医大学唐都医院药剂科,陕西西安710038

出　　处：《现代肿瘤医学》2007年第12期1788-1790,共3页Journal of Modern Oncology

摘　　要：目的:比较格拉司琼与恩丹西酮防治食管癌术后患者化疗引起恶心、呕吐的作用及毒副反应。方法:回顾性研究439例食管癌术后化疗患者的临床资料,比较格拉司琼和恩丹西酮的治疗效果及毒副反应。结果:吻合口位于颈部患者比位于胸内患者易发生恶心、呕吐。格拉司琼对化疗后急性(1d)恶心、呕吐有效率为81.6%,延迟性恶心呕吐(2～5d)的有效率分别为75.0%、64.2%、60.8%、56.1%。恩丹西酮对化疗后急性恶心、呕吐有效率为71.4%,延迟性恶心、呕吐的有效率分别为68.7%、57.7%、52.0%、47.1%,两组差异显著(P<0.05),格拉司琼治疗效果优于恩丹西酮。两者不良反应基本相似。结论:格拉司琼对于防治食管癌术后患者化疗所致恶心、呕吐效果较好。Objective： To explore the efficacy and side effect of granisetron （gran） and ondansetron （onda） on chemotherapy- induced nausea and vomiting（CINV） in post -operative esophageal carcinoma patients （POECP）. Methods： To study the clinical data of 439 POECP undergoing chemotherapy, retrospectively, and to compare the preventive and side effect of gran and onda. Results： CINV were found more likely in patients with anastomosis in the neck than that in thorax. The efficacy rate of gran in acute （dl） CINV was 81.6%, and in delayed （d2 to dS） CINV were75.0%, 64.2%, 60. 8% and 56. 1%, respectively. The efficacy rate of onda in acute CINV were 71.4%, and in delayed CINV were 68.7%, 57.7%, 52.0% and 47.1%, respectively. There was distinct difference between them （P 〈 0.05 ）, the therapeutic effect of gran was better than that of onda, but their side effects were similar. Conclusion： In treatment of CINV in POECP, gran is effective.

关 键 词：格拉司琼 恩丹西酮 化疗 恶心 呕吐 

分 类 号：R735.1[医药卫生—肿瘤]