胃肝样腺癌的免疫病理特点分析—附1例病例报告  

Immunohistochemical and pathological analysis of Hepatoid adenocarcinoma of the stomach:1 case report

作　　者：王燕 谢华红[2] 刘杰[2] 

机构地区：[1]西安解放军323医院,陕西西安710054 [2]西安第四军医大学西京医院消化内科,陕西西安710032

出　　处：《现代肿瘤医学》2007年第12期1810-1812,共3页Journal of Modern Oncology

摘　　要：目的:报道1例伴有神经内分泌特征的胃肝样腺癌,分析其病理组织形态学特点及临床表现。方法:组织形态学结合免疫组织化学研究。结果:本例胃肝样腺癌患者血清AFP水平显著升高;组织学检查显示该肿瘤由类似肝细胞肝癌和腺癌两种病变组成;免疫组织化学染色显示,病变组织表达AFP、PLAP和HCG。结论:伴PLAP和HCG表达的胃肝样腺癌属于未分化癌,未分化癌其组织学特点与胃肝样腺癌相似;胃肝样腺癌伴有PLAP和HCG表达的机制及其生物学行为有待深入研究。Objective：To report 1 case of hepatoid adenocarcinoma with neuroendocrine characteristic of the stomach （HAS） and analyze its histopathological and clinical manifestations. Methods： Histological features and differential diagnosis of HAS were discussed in combination with literature review. Immunohistochemistry was conducted to evaluate the expression of AFP, PLAP, and HCG. Results： Histopathological analysis revealed that the tumor was composed with two pathological changes, which were similar with hepatocellular carcinoma or adenocarcinoma. AFP, PLAP, and HCG were found positive in the specimen of tumor by immunohistochemistry. The serum alpha -fetoprotein （AFP） level of this patient was markedly increased. Conclusion： with the expression of PLAP and HCG belongs to undifferentiated carcinoma. Further study is needed on the mechanisms and biological behaviour of HAS with the expressing PLAP and HCG.

关 键 词：胃肝样腺癌 病理表现 免疫组织化学 PLAP HCG 

分 类 号：R735.2[医药卫生—肿瘤]