原发性侧索硬化临床分析  

Clinical analysis of primary lateral sclerosis

作　　者：卢少军[1] 龚林[1] 赖福生[1] 孙月娟[1] 焦冬生[1] 

机构地区：[1]解放军第454医院神经科,江苏南京210002

出　　处：《新乡医学院学报》2007年第6期615-617,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨原发性侧索硬化(PLS)的临床特点及观察自体骨髓干细胞移植的近期疗效。方法分析4例PLS患者的临床资料,并结合文献复习。结果本组PLS患者主要临床特点为:起病隐袭、逐渐加重;四肢肌无力、肌张力增高、腱反射亢进、病理征阳性、假性延髓麻痹症状。自体骨髓干细胞移植7 d后,4例患者肢体发僵减轻,肢体活动变得灵活,2例有假性延髓麻痹症状患者吞咽困难好转,言语变得流利。单手握力治疗后(19.70±8.86)kg,较治疗前(16.95±9.34)kg明显增加(t=4.609,P=0.002)。结论PLS的临床特点是慢性进行性上运动神经元损害;自体骨髓干细胞移植治疗有较好近期疗效。Objective To investigate the clinical features of primary lateral sclerosis（PLS） and to observer the short-term effect of autograft of marrow stem cells（MSCs） on it. Methods The clinical data of 4 cases of PLS were analyzed with review of literature. Results The mainly clinical features of the patients with PLS included：insidious onset, slowly progressive,four limbs amyosthenia, hypermyotonia, tendon hyperreflexia, positive pathologic reflexes and pseudobulbar palsy symptom. Seven days after autograft of marrow stem cells,the symptoms were improved, such as rigidity of extremities reduced, dysphagia and speech disturbance improved, The holding force of single hand was better posttreatment （19.70 ± 8. 86） kg than pretreatment （16.95 ± 9.34） kg（t =4. 609 ,P = 0.002）. Conclusion The clinical feature of PLS was chronic and progressive upper motor neuron damage. MSCs treating PLS has a better short-term effect.

关 键 词：原发性侧索硬化 骨髓干细胞 移植 

分 类 号：R744[医药卫生—神经病学与精神病学]