脑钠肽和肌钙蛋白Ⅰ联合检测对急性肺栓塞预后评估的意义  

The Significance of Combined BNP and cTnⅠ Tests to Evaluate the Prognosis of Acute Pulmonary Embolism

作　　者：李炳华[1] 王惠阁[1] 张金卓[1] 宋建民[1] 陈春玲[1] 

机构地区：[1]河北省保定市第一中心医院呼吸科,河北保定071000

出　　处：《中国药业》2007年第23期54-55,共2页China Pharmaceuticals

摘　　要：目的探讨急性肺栓塞(APE)患者血浆脑钠肽(BNP)和肌钙蛋白Ⅰ(cTnⅠ)水平对预后评估的价值。方法20例APE患者通过胸部增强螺旋CT、肺核素扫描、磁共振确诊。结果BNP>100pg/mL的患者共8例,BNP<100pg/mL的患者共12例,BNP升高组心源性休克发生率及院内死亡率均高于BNP正常组(P<0.05),且BNP水平与右心室舒张末内径显著相关(r=0.739)。cTnⅠ>0.05ng/mL的患者共9例,cTnⅠ<0.05ng/mL的患者共11例,cTnⅠ水平与APE患者心血管不良事件显著相关(OR=27.65,95%CI=4.67%～148.65%)。结论BNP和cTnⅠ可作为判断APE的预后指标,有助于明确危险分层,指导治疗。Objective To study the dynamic change of brain natriuretic peptid （BNP） and cardial tropnin （cTnI） in acute pulmonary embolism （APE） and to evaluate the significance of plasm BNP and cTn I to the prognosis of APE. Methods 20 APE patients were confirmed by ventilationperfusion lung scan, spiral computed tomography （sCT）, magnetic imaging （MRI）. Results There were 8 cases of BNP 〉 100 pg/mL and 12 cases of BNP 〈 100 pg/mL. The occurrance rate of shock and the fatality rate in the increasing BNP group were higher than those in the normal BNP group （P 〈 0.05）. The BNP level was closely correlated with right vcntricular end diastolic dimension（RVEDD, r =0. 739）. There were 9 cases of eTn I 〉 0.05 ng/mL anti 11 cases of cTn I 〈 0.05 ng/ml,. The cTn I level was closely correlated with adverse cardiovascular events （P 〈 0.05）. Conclusion cTn I and BNP can be used as the prognostic indications for APE and he beneficial to definie risk grade and guide trealmenl.

关 键 词：急性肺栓塞 右心室功能障碍 脑钠肽 肌钙蛋白I 预后 

分 类 号：R363.2[医药卫生—病理学] R563.5[医药卫生—基础医学]