藻酸双酯钠对急性脑梗死患者血小板α颗粒膜蛋白的影响  

Effect of polysaccharide sulfate on plasma alpha-granule membrane protein in patients with acute cerebral infarction

作　　者：马丽丽[1] 王兆钺[1] 尹明达 

机构地区：[1]苏州大学附属第一医院,苏州215006 [2]开封市第一人民医院神经内科,开封475000

出　　处：《中国实用神经疾病杂志》2007年第9期11-14,共4页Chinese Journal of Practical Nervous Diseases

摘　　要：目的研究藻酸双酯钠对急性脑梗死患者血小板a颗粒膜蛋白的影响及临床疗效。方法将急性脑梗死患者随机分藻酸双酯钠(PSS)、阿司匹林(ASA)与噻氯匹定(TP)3个治疗组,测量治疗前及治疗后3d、7d、14d的血小板α颗粒膜蛋白-140含量,并观察治疗前后临床神经功能状况。结果3组治疗后3d、7d、14d血浆GMP-140水平较治疗前明显降低,PSS组患者的神经功能恢复优于ASA与TP组。结论PSS具有抗血小板聚集作用,能有效改善急性脑梗死患者神经功能缺损症状,提高其日常生活能力。Objective To study the effect of polysaccharide sulfate on plasma alpha-granule membrane protein （GMP-140） and clinical significance in patients with acute cerebral infarction（ACI）. Methods The patients suffering from ACI within one week were randomly derided into three groups and received polysaccharide sulfate （PSS）, aspirin （ASA） and ticlopidine （TP） respectively. The level of plasma GMP-140 and the score of nervous function were measured before treatment and 3d,7d, 14d after treatment. Results The levels of plasma GMP- 140 in patients of three groups were obviously decreased in 3d, 7d and 14d after treatment than before treatment. Nervous function was recovered better in PSS group than in ASA and TP groups. Conclusion PSS shows an effect in platelet inhibition. It can remarkably improve nervous function deficiency and life abilities of ACI patients.

关 键 词：藻酸双酯钠 血小板Α颗粒膜蛋白-140 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]