应用功能性磁共振成像技术探讨针刺三阴交穴对脑功能的调节作用  

The effect of acupuncture at the acupoint Sanyinjiao on brain function as revealed by the functional magnetic resonance imaging

作　　者：陈文君[1] 寿依群[1] 李建华[1] 许志生[1] 刘海[2] 

机构地区：[1]浙江大学医学院附属邵逸夫医院康复医学科,杭州310016 [2]浙江大学医学院附属邵逸夫医院放射科,杭州310016

出　　处：《中华物理医学与康复杂志》2007年第11期774-779,共6页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的观察手捻针刺三阴交穴对脑组织功能性磁共振成像(fMRI)的影响,分析针刺三阴交穴对大脑不同区域功能的调节作用,从现代科学角度对针刺三阴交穴的可能作用机理进行初步探讨。方法应用磁共振成像系统,对8名健康右利手志愿者接受针刺右侧三阴交穴期间的功能活动进行全脑扫描,获得针刺三阴交穴的脑功能激活图。8名自愿者的数据经过空间平滑、头动矫正等处理后进行平均化,通过反卷积计算每个体素的信号改变,定义P<0.001为差异具有统计学意义。结果针刺右侧三阴交穴可激活左右额内侧回、有额中回、左额下回、双侧中央旁小叶、左右中央前回、左右中央后回、左侧顶下小叶、双侧楔前叶、右颞中回、右扣带回、右扣带后回、双侧颞上回、双侧颞横回、双侧岛叶和双侧丘脑。结论针刺三阴交穴可激活额、顶、颞叶皮质以及扣带回、楔前叶、岛叶、丘脑,可能是其治疗泌尿、生殖、消化系统疾病和下肢神经痛、瘫痪,以及改善精神和睡眠状态的作用机制。针刺三阴交穴能引起双侧特定脑皮质的反应,进一步证实穴位与脑皮质相应代表区之间存在相关性。Objective To investigate the effect of acupuncture at Sanyinjiao with functional magnetic reso- nance imaging （fMRI） , analyse the regulating effect of the acupoint Sanyinjiao on various brain areas, explore the mechanisms of Sanyinjiao （SP. 6） acupuncture in treating diseases. Methods Eight right-handed healthy volunteers were scanned at 1.5 Tesla magnetic resonance imaging scanner while they were acupunctured at the right Sanyinjiao acupoint. Image data were co-registered to correct head motion, spatial normalization and deconverlution analysis were conducted. Functional activation maps were generated. Results There observed certain activation in both sides of medial frontal gyrus, right middle frontal gyrus, left inferior frontal gyrus, both sides of paracentral lobule, precentral gyrus and postcentral gyrus, left inferior parietal lobule, both sides of precuneus, right middle temporal gyrus, right cingulated gyrus, posterior cingulated gyrus, both sides of superior temporal gyrus, transverse temporal gyrus, insula and thalamus. Conclusion Acupuncturing the Sanyinjiao can lead to the functional changes in parietal lobe, frontal lobe, temporal lobe and insula, precuneus, cingulated gyrus, thalamus, which are closely related to the therapeutical effects of Sanyinjiao. The phenomenon that needling Sanyinjiao can activate certain brain areas proved the correlation between acupoint and corresponding brain cortices.

关 键 词：功能性磁共振成像 脑 针刺效应 三阴交穴 

分 类 号：R445.2[医药卫生—影像医学与核医学] R245[医药卫生—诊断学]