肿瘤标志物在结肠癌诊疗中的应用  

The Clinical Application of Tumor Markers in Colorectal Cancer

作　　者：朱传金[1] 彭莉[1] 刘美琴[1] 赵慧红[1] 

机构地区：[1]山东省肿瘤医院,山东济南250117

出　　处：《肿瘤基础与临床》2007年第6期487-488,共2页journal of basic and clinical oncology

摘　　要：目的探讨肿瘤标志物单项检测或联检在结肠癌诊断、随访、预后及疗效观察中的应用。方法用电化学发光方法检测结肠癌105例、良性肠道疾病30例、健康对照40例血浆中CEA、CA19-9、CA72-4、CA242的含量。结果结肠癌患者CEA、CA19-9、CA72-4、CA242的含量明显大于良性肠道疾病患者和健康对照组(P<0.01)。63例结肠癌根治术后肿瘤标志物明显下降(P<0.01)。结论肿瘤标志物可用于结肠癌的诊断、预后、疗效观察、复发和早期转移诊断。Objective To discuss the clinical value of using one tumor marker or several tumor markers together in colorectal cancer. Methods By electrochemiluminescence method, the serum levels of CEA, CA19-9, CA72-4, CA242 in 105 colorectal cancer patients and 30 benign intestinal patients and 40 healthy adults. Results The serum levels of CEA, CA19-9, CA72-4, CA242 were significantly higher in colorectal cancer patients than those in benign intestinal patients and healthy adults （P 〈 0.01 ）. In patients after colorectal cancer radical operation, their serum levels of tumor markers were significantly lower（P 〈 0.01 ）. Conclusions The tumor markers can be used in the diagnosis, judging curing effect, prognosis, recrudescence and the early diagnosis of metastases.

关 键 词：结肠癌 肿瘤标志物 诊断 

分 类 号：R735.35[医药卫生—肿瘤] R730.43[医药卫生—临床医学]