全身伽玛刀治疗纵隔转移瘤65例近期疗效观察  

The Observation of the Short Term Therapeutic Effectiveness of Body γ-Knife in 65 Patients with Mediastinum Metastases

作　　者：张现军[1] 单国用[1] 陈永顺[1] 张大勇[1] 

机构地区：[1]郑州市第五人民医院放疗科,河南郑州450053

出　　处：《肿瘤基础与临床》2007年第6期518-519,共2页journal of basic and clinical oncology

摘　　要：目的观察全身伽玛刀治疗纵隔转移瘤的近期疗效与放射反应。方法应用全身伽玛刀治疗纵隔转移瘤65例，肿瘤组织照射剂量单次3-4Gy，总量60—65Gy，13—16次完成。治疗结束后2个月采用CT复查纵隔转移瘤情况。结果病灶完全缓解（CR）51例，部分缓解（PR）10例，无变化（NC）4例，无进展病例。急性放射性气管炎发生率Ⅰ级24．6％（16／65），无Ⅱ-Ⅳ级发生；急性放射性食管炎发生率Ⅰ级13．8％（9／65），无Ⅱ-Ⅳ级发生。结论全身伽玛刀治疗纵隔转移瘤近期疗效显著，是一种安全、可靠的治疗方法，远期反应有待随访观查。Objective To investigate the short term therapeutic effectiveness and side-effect of body γ-knife in patients with mediastinum metastases. Methods 65 patients with mediastinum metastases were treated by body γ-knife. The method of radiotherapy was 3-4 Gy per fraction with a total dose of 60-65 Gy in 13-16 times. Results All patients received CT test to observe the therapeutic effectiveness after two months. 51 cases were found with complete response（CR） , 10 with partial response（ PR）, 4 with no change（ N C）, no one with progression of disease. Grade Ⅰ radiation pneumonitis and esophagitis occurred in 24.6% and 13.8% with no grade Ⅱ-Ⅳ ones. Conclusions Body γ- knife could obtain a high local control rate. The short term therapeutic effectiveness is satisfactory. Body γ-knife is a safe and reliable treatment option for patients with mediastinum metastases.

关 键 词：全身伽玛刀 纵隔转移瘤 近期疗效 

分 类 号：R730.55[医药卫生—肿瘤] R734.5[医药卫生—临床医学]